154508

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2132704..2133190 Replicon chromosome
Accession NZ_CP051624
Organism Streptococcus dysgalactiae subsp. equisimilis strain TPCH-A74

Toxin (Protein)


Gene name relE Uniprot ID Q48QR0
Locus tag HHM65_RS10575 Protein ID WP_014407961.1
Coordinates 2132704..2132973 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A660A1J7
Locus tag HHM65_RS10580 Protein ID WP_014407962.1
Coordinates 2132963..2133190 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHM65_RS10560 2127836..2130109 - 2274 WP_015058145.1 YhgE/Pip domain-containing protein -
HHM65_RS10565 2130244..2130777 + 534 WP_003059589.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
HHM65_RS10570 2130774..2132276 - 1503 WP_170078213.1 IS1182 family transposase -
HHM65_RS10575 2132704..2132973 - 270 WP_014407961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHM65_RS10580 2132963..2133190 - 228 WP_014407962.1 hypothetical protein Antitoxin
HHM65_RS10585 2133343..2133715 - 373 Protein_2027 ArpU family transcriptional regulator -
HHM65_RS10590 2133690..2134052 - 363 WP_015058149.1 DUF1492 domain-containing protein -
HHM65_RS10595 2134331..2134576 - 246 WP_011285304.1 hypothetical protein -
HHM65_RS10600 2134551..2134826 - 276 WP_014407964.1 hypothetical protein -
HHM65_RS10605 2134816..2135154 - 339 WP_030126557.1 replication protein -
HHM65_RS10610 2135196..2135462 - 267 WP_011285307.1 hypothetical protein -
HHM65_RS10615 2135459..2136247 - 789 WP_015058150.1 hypothetical protein -
HHM65_RS10620 2136338..2136496 - 159 WP_015058151.1 hypothetical protein -
HHM65_RS10625 2136510..2136755 - 246 WP_015058152.1 hypothetical protein -
HHM65_RS10630 2136751..2137077 - 327 Protein_2036 hypothetical protein -
HHM65_RS10635 2137079..2137252 - 174 WP_015058154.1 hypothetical protein -
HHM65_RS10640 2137258..2137431 - 174 WP_015058155.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2110599..2162216 51617
- flank IS/Tn - - 2130774..2132276 1502


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10497.50 Da        Isoelectric Point: 10.5027

>T154508 WP_014407961.1 NZ_CP051624:c2132973-2132704 [Streptococcus dysgalactiae subsp. equisimilis]
MTYKLVVSDEVKKQLKKMDKHVGLMLAKDMKKRLDGLNNPRQFGKALTGQYKGLWRYRVGNYRVICDIVDNEMIILALEV
GHRKEIYKR

Download         Length: 270 bp

>T154508 NZ_CP068135:c1798664-1797927 [Bacillus cereus]
ATGATCTCTAACATTCGAATTGGCTTATTTGTTTTAGCGATTGTCTTTGTAGTCCTTGTTTTCTTTTATTGGAAAAATGA
GGAGTTGTACGAGGAGAAAAAGCAACGTATTAGAAAGACTTGGTATGGTTTGTTTATCATATCTGTCACCGTGTATTTCA
TGATAAAAGGAATCGATTTAACCCTCTGGAAAAATCTTTTAATGTTTACTGCAATGGTTATTTTTGTTGATATTGCGTTC
ATTTTAACGCCTAATATTTCAGAAATATGGGGTGCAAAATTTAGCGATATTGGCAAGACAGTTCAATCCATAAAACGATC
ATTAATTGCATCTAAAGCAAGAGGAGAAATATACACGACAATTATTCAAAATGTTAATCCAGCAGTATTCGGTACGATGG
AATGGCATACGGAAGAGGAATATACAAAGAGCTTAAATGCATTTTTAGATTCATATGGGGAAAAGATTGGCGCGAAAATT
GTTGTTTTTGAAGCTGCGAAGGAATTAAATACAAACTTTCGTGGTATTCGCTCACAATTTAGTATTATCGTCCCGTTAGA
ACATATCGAGCAATTGAATGAGCAGAAAGCGGTGCAAGTGGAAAATGTCGGGATTATACCAGCAAAAATAGTAAGTGACG
TTTTCATTGTTATTGATGGAAAGAAAAATAACCTGCAAGATCGGGATTTTGAAAATGTATATAATTTAACAATACATCAT
AGTTATTTTAGTAAATAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8641.63 Da        Isoelectric Point: 3.9607

>AT154508 WP_014407962.1 NZ_CP051624:c2133190-2132963 [Streptococcus dysgalactiae subsp. equisimilis]
MAMVSLRLNSAEEELFRSYATHTGKTLSELFKTALAQQIEDQLDYETGIQALKRFEENPITYSIDDLIEELENDL

Download         Length: 228 bp

>AT154508 NZ_CP068135:c1797814-1797686 [Bacillus cereus]
GTGGTAAAAGATTATGACAATGATTTTTTTAAAGAGGATAACGAAGATACAACAGATTTCTCTTTAATAAAAGGGGATAC
GTTGCAGCAAGTAGAAGAATTAGAAGAAGAATTAAAAAGAAAATCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A660A202

Antitoxin

Source ID Structure
AlphaFold DB A0A660A1J7

References