154485

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 3454433..3455253 Replicon chromosome
Accession NZ_CP051615
Organism Escherichia coli O25b:H4-ST131 strain 2017_APHA

Toxin (Protein)


Gene name yjhX Uniprot ID B6I030
Locus tag HHM36_RS16410 Protein ID WP_001054379.1
Coordinates 3454996..3455253 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag HHM36_RS16405 Protein ID WP_000123957.1
Coordinates 3454433..3454984 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHM36_RS16380 3450127..3451440 - 1314 WP_000460845.1 galactitol-specific PTS transporter subunit IIC -
HHM36_RS16385 3451452..3451730 - 279 WP_000722973.1 PTS sugar transporter subunit IIB -
HHM36_RS16390 3451727..3452848 - 1122 WP_000010833.1 M42 family metallopeptidase -
HHM36_RS16395 3453247..3453507 - 261 WP_000077645.1 hypothetical protein -
HHM36_RS16400 3453635..3454381 - 747 WP_000354249.1 class I SAM-dependent methyltransferase -
HHM36_RS16405 3454433..3454984 - 552 WP_000123957.1 N-acetyltransferase Antitoxin
HHM36_RS16410 3454996..3455253 - 258 WP_001054379.1 YjhX family toxin Toxin
HHM36_RS16415 3455630..3455794 - 165 Protein_3205 GNAT family N-acetyltransferase -
HHM36_RS16425 3457100..3458143 + 1044 WP_001363826.1 hypothetical protein -
HHM36_RS16430 3458726..3459706 - 981 WP_000991462.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(19-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9568.07 Da        Isoelectric Point: 11.1381

>T154485 WP_001054379.1 NZ_CP051615:c3455253-3454996 [Escherichia coli O25b:H4-ST131]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

>T154485 NZ_CP068096:c1180800-1179478 [Serratia plymuthica]
ATGCGTCGTTCGCAACAACGGTTAGCTATCTGGATGAATAGTATTCCGGTGGGATACTGGGAAAAGCGCAAAGGTGAAGA
TCGGCTGGAATATCTGCCTGGTTGGATTGCAGATAACCAGGGGAGACCTTTGTCGCTTTCTTTGCCTTTCACGCCGGGGA
ACCAGCCTTATCGCGGTAGCGTGGTGCGCGATTATTTCGATAACCTGCTGCCGGATAGCGAGGGGATCCGCCGACGTCTG
GCAATGCGTTTTCATGCCGAAAGCCTTGATCCTTTTGATTTACTGACTGAACTGGGCCGCGACTGTGTGGGTGCCATACA
ACTTCTTGATATTGATGAGCAACCCACCCATATATTTTCCATCAGGCAGCGCCCACTTTCAGAGGCGCAAATTGCCGAAA
TGCTCCGCAATACTGCCACGATGTTACCGGGGCGACAGGGTCAGGATGACGATCTGCGCTTATCCATCGCCGGCGCTCAG
GAAAAAACAGCGCTGTTGTGGCACGACAACCGGTGGTGTTTACCTGAGGGAAATACGCCGACCACGCATATATTTAAATT
AGCGCTGGGGCTGGTGGGGAATATGCGGGCCGATATGAGCACATCCATCGAGAATGAATGGCTCTGCTCTCTGATTCTTG
AACACTATGGTGTGCCTGTCGCAAGAACGGCTATTGCGCAGTTTGAAGATCAAAAGGCGCTGATCGTTGAGCGTTTTGAC
AGGAAGCTATCAAGTGATGGGCAGTGGTGGATCCGCCTGCCGCAAGAGGATATGTGCCAGGCTCTGGGCGTTTCGCCGCT
GAAGAAGTATCAGTCAGACGGTGGCCCCGGTATTACAGATATTATGGAAGTTCTGAGTCGCTCGGATCAGGCTGAAACAG
ATCGCAGGCGCTTTTTTAAGGCGCAGATTATTTTTTGGTTGCTGGCCGCGACCGATGGCCACGCAAAGAATTTCAGTCTT
GCGCATTTACCGCAAAATCGTTACCACCTGACGCCCCTGTACGATGTGTTATCGGCCTGGCCGCTGATTGGCCCGGGGAA
TAGCCAGATAGCCTGGCAGAAGTGCAAACTGGCGATGGCCGTTCGCGGGAGCAGTAACTATTACCACATTAGCCAGATCC
GACGCCGCCACTGGATAAAACACGGTGAAATAACCGGGTTAGGCCAACAGGAAGTTGAATCCATTATTGAAGAGCTGCTG
GCGGCAACCCCGGGAGTTATTGATCTGGTCGCTGGCCTGCTGCCTGATTCGTTTTCGCCTGAATTAGCGGCATGTATTTT
TGATGGTATCAGGCAGCAGTGTGCGCGGCTGAAAGGGAGATAG

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20358.34 Da        Isoelectric Point: 6.4182

>AT154485 WP_000123957.1 NZ_CP051615:c3454984-3454433 [Escherichia coli O25b:H4-ST131]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Download         Length: 552 bp

>AT154485 NZ_CP068096:c1181101-1180805 [Serratia plymuthica]
ATGAATACCGTCTATCCGTTAAAAACACTGAGCCAATTACGCCCTTTGCTGGTGGGTTTTCGTAAAGCGAAAGGTCTGAC
GCAAAAAGACGTCTCTGAGAGGCTGGGCGTCACCCAGCAGACCTACGCACGCCTGGAGTCAAACCCCGCTTCAGCCAGCC
TGGAACGCCTGTTTCGGGTGTTTAATGTGCTGGGCATTGAAGTGGTGCTTTCCTCAGAGCTGACCTCTCCGGGATGTGAA
ACGGAGGATACCTCTACAACTCATATAGACTCGCCCGCCAGGCGGGAACAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B6I030

Antitoxin

Source ID Structure

References