Detailed information of TA system TA154485

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 3454433..3455253
• Replicon: chromosome
• Accession: NZ_CP051615
• Organism: Escherichia coli O25b:H4-ST131 strain 2017_APHA

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: HHM36_RS16410
• Protein ID: WP_001054379.1
• Coordinates: 3454996..3455253 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: HHM36_RS16405
• Protein ID: WP_000123957.1
• Coordinates: 3454433..3454984 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHM36_RS16380	3450127..3451440	-	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-
HHM36_RS16385	3451452..3451730	-	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
HHM36_RS16390	3451727..3452848	-	1122	WP_000010833.1	M42 family metallopeptidase	-
HHM36_RS16395	3453247..3453507	-	261	WP_000077645.1	hypothetical protein	-
HHM36_RS16400	3453635..3454381	-	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
HHM36_RS16405	3454433..3454984	-	552	WP_000123957.1	N-acetyltransferase	Antitoxin
HHM36_RS16410	3454996..3455253	-	258	WP_001054379.1	YjhX family toxin	Toxin
HHM36_RS16415	3455630..3455794	-	165	Protein_3205	GNAT family N-acetyltransferase	-
HHM36_RS16425	3457100..3458143	+	1044	WP_001363826.1	hypothetical protein	-
HHM36_RS16430	3458726..3459706	-	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T154485 WP_001054379.1 NZ_CP051615:c3455253-3454996 [Escherichia coli O25b:H4-ST131]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T154485 NZ_CP068096:c1180800-1179478 [Serratia plymuthica]
ATGCGTCGTTCGCAACAACGGTTAGCTATCTGGATGAATAGTATTCCGGTGGGATACTGGGAAAAGCGCAAAGGTGAAGA
TCGGCTGGAATATCTGCCTGGTTGGATTGCAGATAACCAGGGGAGACCTTTGTCGCTTTCTTTGCCTTTCACGCCGGGGA
ACCAGCCTTATCGCGGTAGCGTGGTGCGCGATTATTTCGATAACCTGCTGCCGGATAGCGAGGGGATCCGCCGACGTCTG
GCAATGCGTTTTCATGCCGAAAGCCTTGATCCTTTTGATTTACTGACTGAACTGGGCCGCGACTGTGTGGGTGCCATACA
ACTTCTTGATATTGATGAGCAACCCACCCATATATTTTCCATCAGGCAGCGCCCACTTTCAGAGGCGCAAATTGCCGAAA
TGCTCCGCAATACTGCCACGATGTTACCGGGGCGACAGGGTCAGGATGACGATCTGCGCTTATCCATCGCCGGCGCTCAG
GAAAAAACAGCGCTGTTGTGGCACGACAACCGGTGGTGTTTACCTGAGGGAAATACGCCGACCACGCATATATTTAAATT
AGCGCTGGGGCTGGTGGGGAATATGCGGGCCGATATGAGCACATCCATCGAGAATGAATGGCTCTGCTCTCTGATTCTTG
AACACTATGGTGTGCCTGTCGCAAGAACGGCTATTGCGCAGTTTGAAGATCAAAAGGCGCTGATCGTTGAGCGTTTTGAC
AGGAAGCTATCAAGTGATGGGCAGTGGTGGATCCGCCTGCCGCAAGAGGATATGTGCCAGGCTCTGGGCGTTTCGCCGCT
GAAGAAGTATCAGTCAGACGGTGGCCCCGGTATTACAGATATTATGGAAGTTCTGAGTCGCTCGGATCAGGCTGAAACAG
ATCGCAGGCGCTTTTTTAAGGCGCAGATTATTTTTTGGTTGCTGGCCGCGACCGATGGCCACGCAAAGAATTTCAGTCTT
GCGCATTTACCGCAAAATCGTTACCACCTGACGCCCCTGTACGATGTGTTATCGGCCTGGCCGCTGATTGGCCCGGGGAA
TAGCCAGATAGCCTGGCAGAAGTGCAAACTGGCGATGGCCGTTCGCGGGAGCAGTAACTATTACCACATTAGCCAGATCC
GACGCCGCCACTGGATAAAACACGGTGAAATAACCGGGTTAGGCCAACAGGAAGTTGAATCCATTATTGAAGAGCTGCTG
GCGGCAACCCCGGGAGTTATTGATCTGGTCGCTGGCCTGCTGCCTGATTCGTTTTCGCCTGAATTAGCGGCATGTATTTT
TGATGGTATCAGGCAGCAGTGTGCGCGGCTGAAAGGGAGATAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT154485 WP_000123957.1 NZ_CP051615:c3454984-3454433 [Escherichia coli O25b:H4-ST131]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT154485 NZ_CP068096:c1181101-1180805 [Serratia plymuthica]
ATGAATACCGTCTATCCGTTAAAAACACTGAGCCAATTACGCCCTTTGCTGGTGGGTTTTCGTAAAGCGAAAGGTCTGAC
GCAAAAAGACGTCTCTGAGAGGCTGGGCGTCACCCAGCAGACCTACGCACGCCTGGAGTCAAACCCCGCTTCAGCCAGCC
TGGAACGCCTGTTTCGGGTGTTTAATGTGCTGGGCATTGAAGTGGTGCTTTCCTCAGAGCTGACCTCTCCGGGATGTGAA
ACGGAGGATACCTCTACAACTCATATAGACTCGCCCGCCAGGCGGGAACAGTGGTGA

Structures

Toxin

• AlphaFold DB: B6I030