Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3324207..3324802 Replicon chromosome
Accession NZ_CP051615
Organism Escherichia coli O25b:H4-ST131 strain 2017_APHA

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag HHM36_RS15765 Protein ID WP_000239579.1
Coordinates 3324452..3324802 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag HHM36_RS15760 Protein ID WP_001223208.1
Coordinates 3324207..3324458 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHM36_RS15750 3319872..3323651 + 3780 WP_000060945.1 autotransporter assembly complex protein TamB -
HHM36_RS15755 3323654..3323995 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
HHM36_RS15760 3324207..3324458 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
HHM36_RS15765 3324452..3324802 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
HHM36_RS15770 3324882..3325412 - 531 WP_000055075.1 inorganic diphosphatase -
HHM36_RS15775 3325722..3326678 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
HHM36_RS15780 3326818..3328320 + 1503 WP_000205813.1 sugar ABC transporter ATP-binding protein -
HHM36_RS15785 3328334..3329356 + 1023 WP_001296689.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T154483 WP_000239579.1 NZ_CP051615:3324452-3324802 [Escherichia coli O25b:H4-ST131]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T154483 NZ_CP068096:c19426-19112 [Serratia plymuthica]
ATGCAATTTACGGTATACGCGAATACAGGGAAAAGCGCAGTCTATCCTCTGCTGCTTGATGTGACGAGCGATATCATTGG
GCAATTAAATCGCCGAGTTGTGATCCCGTTATTACCCATTGAAAAGTATCCGGCCAGTACTCGCCCGGAACGCTTGAACC
CTTTGGTCAGGCTGGTGGATGACAACGAGTACGCCGTTATGACCCATGAGATGGCAAGTATTCCCGTTCGTATCCTGGGC
GCTGAATTTTGCGATGCTTCCCAATACCGAACCAAGGTGAAAGCCGCAATAGATTTTCTTTTCGACGGTATCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT154483 WP_001223208.1 NZ_CP051615:3324207-3324458 [Escherichia coli O25b:H4-ST131]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT154483 NZ_CP068096:c19665-19429 [Serratia plymuthica]
ATGCCAGTAAAACAACGAACGACCCAAAGCGTTACCATGGCGGTGGAACGCAGTTTACTGAGCCGTGCACGTGAGGCGGG
CATTAACCTCAGTGCTACGCTGAATGCTGCTTTGGATGCAGAATTGCGTCAGCATGAGATGAGAAAATGGAAGGAAGAAA
ACCGAGAAGCGATCGATGCTTTAAATCGTTTTCATGATGAACATGGCTGTTTCAGTGACGAATACAGGACGTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References