Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 1855298..1856132 | Replicon | chromosome |
| Accession | NZ_CP051609 | ||
| Organism | Escherichia coli O25b:H4-ST131 strain 2019_APHA | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | S1PLF5 |
| Locus tag | HHM37_RS08855 | Protein ID | WP_000854690.1 |
| Coordinates | 1855755..1856132 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1P7N8 |
| Locus tag | HHM37_RS08850 | Protein ID | WP_001305076.1 |
| Coordinates | 1855298..1855666 (+) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HHM37_RS08810 | 1850380..1851507 | + | 1128 | Protein_1727 | hypothetical protein | - |
| HHM37_RS08815 | 1851583..1852038 | + | 456 | WP_000581502.1 | hypothetical protein | - |
| HHM37_RS08820 | 1852117..1852350 | + | 234 | WP_000902034.1 | DUF905 family protein | - |
| HHM37_RS08825 | 1852451..1853269 | + | 819 | WP_001234620.1 | DUF945 domain-containing protein | - |
| HHM37_RS08830 | 1853324..1853809 | + | 486 | WP_000849565.1 | antirestriction protein | - |
| HHM37_RS08835 | 1853825..1854301 | + | 477 | WP_001186726.1 | RadC family protein | - |
| HHM37_RS08840 | 1854364..1854585 | + | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
| HHM37_RS08845 | 1854604..1855248 | + | 645 | WP_000094916.1 | hypothetical protein | - |
| HHM37_RS08850 | 1855298..1855666 | + | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| HHM37_RS08855 | 1855755..1856132 | + | 378 | WP_000854690.1 | TA system toxin CbtA family protein | Toxin |
| HHM37_RS08860 | 1856129..1856617 | + | 489 | WP_000761699.1 | hypothetical protein | - |
| HHM37_RS08865 | 1856634..1856831 | + | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
| HHM37_RS08870 | 1856916..1857761 | + | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
| HHM37_RS08875 | 1857830..1858225 | + | 396 | WP_000208384.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | - |
| HHM37_RS08880 | 1858218..1859151 | + | 934 | Protein_1741 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| HHM37_RS08885 | 1859583..1859738 | + | 156 | WP_000729638.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14057.04 Da Isoelectric Point: 9.1510
>T154442 WP_000854690.1 NZ_CP051609:1855755-1856132 [Escherichia coli O25b:H4-ST131]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYAQVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR
Download Length: 378 bp
>T154442 NZ_CP068054:2139165-2139515 [Weizmannia coagulans]
TTGATTGTTAAGCGTGGAGACGTGTACTTCGCCGATCTATCTCCGGTGGTCGGCTCCGAGCAGGGAGGCGTACGTCCTGT
CCTCATTTTACAAAACGACATTGGAAACCGCTTTAGCCCCACTGTCATTGTTGCCGCTATAACAGCGCAAATCCAGAAAG
CAAAATTGCCCACGCATGTGGAAATCGATGCAAAGCGTTACGGTTTGGAAAGGGATTCTGTGATATTGCTTGAACAAATA
CGCACAATCGATAAACAACGCTTAACGGATAAGATTACGCATCTTGATGAAGAAGTCATGGAGAAAATTGACGACGCCCT
GCAAATCAGCCTGGGACTGGTCGAATTTTAG
TTGATTGTTAAGCGTGGAGACGTGTACTTCGCCGATCTATCTCCGGTGGTCGGCTCCGAGCAGGGAGGCGTACGTCCTGT
CCTCATTTTACAAAACGACATTGGAAACCGCTTTAGCCCCACTGTCATTGTTGCCGCTATAACAGCGCAAATCCAGAAAG
CAAAATTGCCCACGCATGTGGAAATCGATGCAAAGCGTTACGGTTTGGAAAGGGATTCTGTGATATTGCTTGAACAAATA
CGCACAATCGATAAACAACGCTTAACGGATAAGATTACGCATCTTGATGAAGAAGTCATGGAGAAAATTGACGACGCCCT
GCAAATCAGCCTGGGACTGGTCGAATTTTAG
Antitoxin
Download Length: 123 a.a. Molecular weight: 13560.39 Da Isoelectric Point: 4.7830
>AT154442 WP_001305076.1 NZ_CP051609:1855298-1855666 [Escherichia coli O25b:H4-ST131]
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
MSDTLPGTTLPDDNKDLPWWGLPCTVTPCFGACLVQEGNRLHYLADRAGIRGRFSDADAYHPDQAFPLLMKQPELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCDYVYLAVYPTPEMKN
Download Length: 369 bp
>AT154442 NZ_CP068054:2138882-2139160 [Weizmannia coagulans]
GTGTCTGAACCTATTTCAACAGAAATTTTAGTCCGCTTGCCGCAGCAGCTGTTGACGGAATTGGACGGATTTGCTGAAAC
TGAAAATATGAATCGCAATGAGTTAATTTACCGTGCCACAAAAATGTATTTAAAAGAACGGAAAAAACGCCAAATCCGCG
AAACGATGAGGCGAGGCTACATGGAAATGGCAAAAATTAATTTGGCGATTGCCTCCGAAGCGATCCAGGCTGAATACGAA
GCAGAACATACAGTTGAAAGCCTAGTAAGCGGGGGGTAA
GTGTCTGAACCTATTTCAACAGAAATTTTAGTCCGCTTGCCGCAGCAGCTGTTGACGGAATTGGACGGATTTGCTGAAAC
TGAAAATATGAATCGCAATGAGTTAATTTACCGTGCCACAAAAATGTATTTAAAAGAACGGAAAAAACGCCAAATCCGCG
AAACGATGAGGCGAGGCTACATGGAAATGGCAAAAATTAATTTGGCGATTGCCTCCGAAGCGATCCAGGCTGAATACGAA
GCAGAACATACAGTTGAAAGCCTAGTAAGCGGGGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|