Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1712923..1713577 Replicon chromosome
Accession NZ_CP051609
Organism Escherichia coli O25b:H4-ST131 strain 2019_APHA

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag HHM37_RS08115 Protein ID WP_000244765.1
Coordinates 1712923..1713330 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag HHM37_RS08120 Protein ID WP_000354050.1
Coordinates 1713311..1713577 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHM37_RS08095 1708880..1710613 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
HHM37_RS08100 1710619..1711329 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HHM37_RS08105 1711354..1712250 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
HHM37_RS08110 1712362..1712883 + 522 WP_001055874.1 flavodoxin FldB -
HHM37_RS08115 1712923..1713330 - 408 WP_000244765.1 protein YgfX Toxin
HHM37_RS08120 1713311..1713577 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
HHM37_RS08125 1713820..1714800 + 981 WP_000886084.1 tRNA-modifying protein YgfZ -
HHM37_RS08130 1714877..1715536 - 660 WP_000250275.1 hemolysin III family protein -
HHM37_RS08135 1715700..1716011 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
HHM37_RS08140 1716056..1717489 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T154441 WP_000244765.1 NZ_CP051609:c1713330-1712923 [Escherichia coli O25b:H4-ST131]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T154441 NZ_CP068053:c2519251-2518901 [Peribacillus psychrosaccharolyticus]
ATTGTTGTGAAACGTGGTGACGTATACTTCGCAGACCTGTCTCCGGTCGTAGGATCAGAACAAGGCGGGACGCGACCAGT
GCTTATCCTTCAGAATGACATTGGAAATCGCTTTAGTCCTACTGTGATTGTAGCAGCCATTACAGCGCAAATTCAAAAAG
CCAAATTGCCTACACACGTTGAAATTAATGCAAAGAAATATGGGTTCGAGCGTGATTCAGTTATTTTACTAGAACAGATC
CGCACAATTGATAAGCAGCGGCTGACTGATAAAATTACTCATCTTGATGAACCGATGATGGAAAAGGTCAAAGATGCTCT
GCAAATTAGTTTAGGACTGGTTGATTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT154441 WP_000354050.1 NZ_CP051609:c1713577-1713311 [Escherichia coli O25b:H4-ST131]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT154441 NZ_CP068053:c2519540-2519259 [Peribacillus psychrosaccharolyticus]
GTGTCTGAATCCAGCGCAACAAGAGAAATTTTAATTCGATTACCTCAAAACTTTTTATCCGAGCTTGATGGGTATGTTTC
TGAAGAAAATGTGAATCGTAGTGAATTTATTTACCATGCGACAAAAGTGTATATTCGTGAAAGAAAAAAAAGAGAATTTC
GCGAATCGATGAAACGTGGTTATATTGAGATGGCAGCCATTAACTTAACAATTGCTTCGGAAGCATTTTTGTTAGAATTT
GAAGCTGACCATTGCGTTGAACGATTAGCTAGCGGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References