Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4602381..4603000 Replicon chromosome
Accession NZ_CP051548
Organism Phytobacter diazotrophicus strain UAEU22

Toxin (Protein)


Gene name Hha Uniprot ID A0A348DII6
Locus tag HHA33_RS21895 Protein ID WP_041852465.1
Coordinates 4602782..4603000 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A348DII5
Locus tag HHA33_RS21890 Protein ID WP_041852464.1
Coordinates 4602381..4602755 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHA33_RS21880 4597492..4598688 + 1197 WP_041852462.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HHA33_RS21885 4598711..4601860 + 3150 WP_169039820.1 multidrug efflux RND transporter permease subunit AcrB -
HHA33_RS21890 4602381..4602755 + 375 WP_041852464.1 Hha toxicity modulator TomB Antitoxin
HHA33_RS21895 4602782..4603000 + 219 WP_041852465.1 hemolysin expression modulator Hha Toxin
HHA33_RS21900 4603069..4603635 + 567 WP_041852466.1 maltose O-acetyltransferase -
HHA33_RS21905 4603735..4604202 + 468 WP_041852467.1 membrane protein -
HHA33_RS21910 4604180..4605625 - 1446 WP_169039821.1 PLP-dependent aminotransferase family protein -
HHA33_RS21915 4605725..4606426 + 702 WP_041852469.1 GNAT family N-acetyltransferase -
HHA33_RS21920 4606423..4606563 - 141 WP_006818844.1 type B 50S ribosomal protein L36 -
HHA33_RS21925 4606567..4606827 - 261 WP_041852470.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8685.14 Da        Isoelectric Point: 8.9039

>T154428 WP_041852465.1 NZ_CP051548:4602782-4603000 [Phytobacter diazotrophicus]
MSDKPLTKIDYLMRLRRCQTIDTLERVIEKNKYELPDHELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

>T154428 NZ_CP068044:54448-54600 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14600.44 Da        Isoelectric Point: 5.5072

>AT154428 WP_041852464.1 NZ_CP051548:4602381-4602755 [Phytobacter diazotrophicus]
MDEYSPKRHDIAQLKFLCETLYHDCLLNLEESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNVSKANPVSHSC

Download         Length: 375 bp

>AT154428 NZ_CP068044:c54398-54336 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A348DII6

Antitoxin

Source ID Structure
AlphaFold DB A0A348DII5

References