Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4602381..4603000 Replicon chromosome
Accession NZ_CP051548
Organism Phytobacter diazotrophicus strain UAEU22

Toxin (Protein)


Gene name Hha Uniprot ID A0A348DII6
Locus tag HHA33_RS21895 Protein ID WP_041852465.1
Coordinates 4602782..4603000 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A348DII5
Locus tag HHA33_RS21890 Protein ID WP_041852464.1
Coordinates 4602381..4602755 (+) Length 125 a.a.

Genomic Context

HHA33_RS21880HHA33_RS21885HHA33_RS21890HHA33_RS21895HHA33_RS21900HHA33_RS21905HHA33_RS21915HHA33_RS21910HHA33_RS21920HHA33_RS21925
Location: 4597492..4598688 (1197 bp)
Type: Others
Protein ID: WP_041852462.1
Location: 4598711..4601860 (3150 bp)
Type: Others
Protein ID: WP_169039820.1
Location: 4602381..4602755 (375 bp)
Type: Antitoxin
Protein ID: WP_041852464.1
Location: 4602782..4603000 (219 bp)
Type: Toxin
Protein ID: WP_041852465.1
Location: 4603069..4603635 (567 bp)
Type: Others
Protein ID: WP_041852466.1
Location: 4603735..4604202 (468 bp)
Type: Others
Protein ID: WP_041852467.1
Location: 4605725..4606426 (702 bp)
Type: Others
Protein ID: WP_041852469.1
Location: 4604180..4605625 (1446 bp)
Type: Others
Protein ID: WP_169039821.1
Location: 4606423..4606563 (141 bp)
Type: Others
Protein ID: WP_006818844.1
Location: 4606567..4606827 (261 bp)
Type: Others
Protein ID: WP_041852470.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HHA33_RS218804597492..4598688+1197WP_041852462.1multidrug efflux RND transporter periplasmic adaptor subunit AcrA-
HHA33_RS218854598711..4601860+3150WP_169039820.1multidrug efflux RND transporter permease subunit AcrB-
HHA33_RS218904602381..4602755+375WP_041852464.1Hha toxicity modulator TomBAntitoxin
HHA33_RS218954602782..4603000+219WP_041852465.1hemolysin expression modulator HhaToxin
HHA33_RS219004603069..4603635+567WP_041852466.1maltose O-acetyltransferase-
HHA33_RS219054603735..4604202+468WP_041852467.1membrane protein-
HHA33_RS219104604180..4605625-1446WP_169039821.1PLP-dependent aminotransferase family protein-
HHA33_RS219154605725..4606426+702WP_041852469.1GNAT family N-acetyltransferase-
HHA33_RS219204606423..4606563-141WP_006818844.1type B 50S ribosomal protein L36-
HHA33_RS219254606567..4606827-261WP_041852470.1type B 50S ribosomal protein L31-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8685.14 Da        Isoelectric Point: 8.9039

>T154428 WP_041852465.1 NZ_CP051548:4602782-4603000 [Phytobacter diazotrophicus]
MSDKPLTKIDYLMRLRRCQTIDTLERVIEKNKYELPDHELTVFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 219 bp

>T154428 NZ_CP068044:54448-54600 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14600.44 Da        Isoelectric Point: 5.5072

>AT154428 WP_041852464.1 NZ_CP051548:4602381-4602755 [Phytobacter diazotrophicus]
MDEYSPKRHDIAQLKFLCETLYHDCLLNLEESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNVSKANPVSHSC

Download         Length: 375 bp

>AT154428 NZ_CP068044:c54398-54336 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A348DII6

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A348DII5

References