154417

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 3062078..3062700 Replicon chromosome
Accession NZ_CP051548
Organism Phytobacter diazotrophicus strain UAEU22

Toxin (Protein)


Gene name hicA Uniprot ID A0A7M2VEM2
Locus tag HHA33_RS14725 Protein ID WP_039079130.1
Coordinates 3062078..3062260 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7M2VD87
Locus tag HHA33_RS14730 Protein ID WP_039079129.1
Coordinates 3062272..3062700 (+) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHA33_RS14710 3058645..3058920 + 276 WP_039079133.1 metal/formaldehyde-sensitive transcriptional repressor -
HHA33_RS14715 3058953..3060071 + 1119 WP_169039313.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
HHA33_RS14720 3060226..3061923 + 1698 WP_071194121.1 Tar ligand binding domain-containing protein -
HHA33_RS14725 3062078..3062260 + 183 WP_039079130.1 type II toxin-antitoxin system HicA family toxin Toxin
HHA33_RS14730 3062272..3062700 + 429 WP_039079129.1 hypothetical protein Antitoxin
HHA33_RS14735 3062741..3065122 - 2382 WP_169039314.1 glucose/quinate/shikimate family membrane-bound PQQ-dependent dehydrogenase -
HHA33_RS14740 3065380..3067677 - 2298 WP_039079127.1 FdhF/YdeP family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7143.27 Da        Isoelectric Point: 10.5371

>T154417 WP_039079130.1 NZ_CP051548:3062078-3062260 [Phytobacter diazotrophicus]
MKYSEFRRWLLEQGAILQKHRRGSSHFKVYLDDRQSIFPDHGAKEMPEGTRKKIIKDLGL

Download         Length: 183 bp

>T154417 NZ_CP068041:c3759675-3759340 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15785.29 Da        Isoelectric Point: 4.7105

>AT154417 WP_039079129.1 NZ_CP051548:3062272-3062700 [Phytobacter diazotrophicus]
MFNYAVKLTQDAETRVYEVSCRDLPLMHSVGDTPEEALLEAEDGIVTAISLEMDMRRPIPVATPAREDERVVIIPVLVAM
KAALYNAMIETGTRKADLARRLGVNAPQVDRLLDVEHSSKVEKVEFALAQLGRKIQVEIQIA

Download         Length: 429 bp

>AT154417 NZ_CP068041:c3759923-3759675 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7M2VEM2

Antitoxin

Source ID Structure
AlphaFold DB A0A7M2VD87

References