Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 2410813..2411403 Replicon chromosome
Accession NZ_CP051548
Organism Phytobacter diazotrophicus strain UAEU22

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag HHA33_RS11455 Protein ID WP_169039137.1
Coordinates 2411071..2411403 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A7M2V158
Locus tag HHA33_RS11450 Protein ID WP_041851870.1
Coordinates 2410813..2411070 (+) Length 86 a.a.

Genomic Context

HHA33_RS11445HHA33_RS11450HHA33_RS11455HHA33_RS11465HHA33_RS11425HHA33_RS11430HHA33_RS11435HHA33_RS11440HHA33_RS11475HHA33_RS11480
Location: 2409478..2410389 (912 bp)
Type: Others
Protein ID: WP_125124237.1
Location: 2410813..2411070 (258 bp)
Type: Antitoxin
Protein ID: WP_041851870.1
Location: 2411071..2411403 (333 bp)
Type: Toxin
Protein ID: WP_169039137.1
Location: 2411808..2413241 (1434 bp)
Type: Others
Protein ID: WP_107224097.1
Location: 2406418..2406753 (336 bp)
Type: Others
Protein ID: WP_132439155.1
Location: 2406881..2407171 (291 bp)
Type: Others
Protein ID: WP_169039135.1
Location: 2407429..2407968 (540 bp)
Type: Others
Protein ID: WP_079496546.1
Location: 2408268..2409377 (1110 bp)
Type: Others
Protein ID: WP_169039136.1
Location: 2413495..2414406 (912 bp)
Type: Others
Protein ID: WP_107224098.1
Location: 2414425..2415699 (1275 bp)
Type: Others
Protein ID: WP_071196351.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HHA33_RS114252406418..2406753-336WP_132439155.1gamma-glutamylcyclotransferase-
HHA33_RS114302406881..2407171-291WP_169039135.1DUF3601 domain-containing protein-
HHA33_RS114352407429..2407968-540WP_079496546.1ester cyclase-
HHA33_RS114402408268..2409377-1110WP_169039136.1alkene reductase-
HHA33_RS114452409478..2410389+912WP_125124237.1LysR family transcriptional regulator-
HHA33_RS114502410813..2411070+258WP_041851870.1antitoxinAntitoxin
HHA33_RS114552411071..2411403+333WP_169039137.1type II toxin-antitoxin system PemK/MazF family toxinToxin
HHA33_RS114652411808..2413241+1434WP_107224097.1EmmdR/YeeO family multidrug/toxin efflux MATE transporter-
HHA33_RS114752413495..2414406-912WP_107224098.1sugar ABC transporter permease-
HHA33_RS114802414425..2415699-1275WP_071196351.1extracellular solute-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(5-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11699.39 Da        Isoelectric Point: 8.0290

>T154416 WP_169039137.1 NZ_CP051548:2411071-2411403 [Phytobacter diazotrophicus]
MDRGEIWLVSLDPTTGHEQSGKRPVLIVSPASFNALTRLSVVVPVTSGGNFARAAGFAVSLDGAGTKTTGVIRCDQPRTI
DMDARNGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

>T154416 NZ_CP068041:c2976337-2976086 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9286.76 Da        Isoelectric Point: 4.5799

>AT154416 WP_041851870.1 NZ_CP051548:2410813-2411070 [Phytobacter diazotrophicus]
MYIARLKKVGGSVMLAVPPAVLKTLGLSTDSEVGMTIENGCLIIEPQKRPHYSLEELLAQCDPHAEISEEDRQWIDAPAA
GKELL

Download         Length: 258 bp

>AT154416 NZ_CP068041:c2976089-2975835 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7M2V158

References