Detailed information of TA system TA154411

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3480707..3481928
• Replicon: chromosome
• Accession: NZ_CP051547
• Organism: Pseudomonas aeruginosa strain AA2

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: HHA37_RS15995
• Protein ID: WP_003102740.1
• Coordinates: 3481350..3481928 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: HHA37_RS15990
• Protein ID: WP_003088112.1
• Coordinates: 3480707..3481261 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HHA37_RS15965	3476275..3476826	+	552	WP_003450159.1	XRE family transcriptional regulator	-
HHA37_RS15970	3476823..3477221	-	399	WP_023089053.1	NADH-quinone oxidoreductase subunit A	-
HHA37_RS15975	3477234..3477557	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
HHA37_RS15980	3477888..3478349	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
HHA37_RS15985	3478354..3480549	+	2196	WP_058007015.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
HHA37_RS15990	3480707..3481261	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
HHA37_RS15995	3481350..3481928	+	579	WP_003102740.1	HD domain-containing protein	Toxin
HHA37_RS16000	3482037..3483224	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
HHA37_RS16005	3483214..3485385	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
HHA37_RS16010	3485375..3486652	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T154411 WP_003102740.1 NZ_CP051547:3481350-3481928 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T154411 NZ_CP068041:2283465-2283641 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT154411 WP_003088112.1 NZ_CP051547:3480707-3481261 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT154411 NZ_CP068041:2283687-2284103 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07