Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 153422..153927 Replicon chromosome
Accession NZ_CP051547
Organism Pseudomonas aeruginosa strain AA2

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag HHA37_RS00700 Protein ID WP_003083773.1
Coordinates 153422..153703 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag HHA37_RS00705 Protein ID WP_003083775.1
Coordinates 153700..153927 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHA37_RS00675 148673..150022 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
HHA37_RS00680 150071..150757 + 687 WP_003083762.1 FadR family transcriptional regulator -
HHA37_RS00685 150858..151592 + 735 WP_003101224.1 GntR family transcriptional regulator -
HHA37_RS00690 151796..152182 + 387 WP_014602345.1 aegerolysin family protein -
HHA37_RS00695 152214..153122 - 909 WP_003083769.1 LysR family transcriptional regulator -
HHA37_RS00700 153422..153703 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
HHA37_RS00705 153700..153927 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
HHA37_RS00710 154103..154723 - 621 WP_003101226.1 hypothetical protein -
HHA37_RS00715 154824..155324 + 501 WP_003101228.1 LEA type 2 family protein -
HHA37_RS00720 155397..155738 + 342 WP_003101229.1 alkylphosphonate utilization protein -
HHA37_RS00725 155820..157247 - 1428 WP_003083784.1 GABA permease -
HHA37_RS00730 157416..158909 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T154409 WP_003083773.1 NZ_CP051547:c153703-153422 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T154409 NZ_CP068041:c2068521-2068414 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT154409 WP_003083775.1 NZ_CP051547:c153927-153700 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT154409 NZ_CP068041:2068568-2068634 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References