Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 31783..32398 Replicon plasmid pPspOM44
Accession NZ_CP051544
Organism Paracoccus sanguinis strain OM2164

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HGN31_RS16140 Protein ID WP_168784087.1
Coordinates 32000..32398 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HGN31_RS16135 Protein ID WP_168784086.1
Coordinates 31783..32010 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGN31_RS16105 27565..28146 - 582 WP_168784082.1 hypothetical protein -
HGN31_RS16110 28229..28438 + 210 WP_036733484.1 helix-turn-helix domain-containing protein -
HGN31_RS16115 29113..29820 - 708 WP_168784095.1 peptidoglycan-binding protein -
HGN31_RS16120 30209..30454 - 246 WP_168784083.1 hypothetical protein -
HGN31_RS16125 30614..31102 - 489 WP_168784084.1 DUF1311 domain-containing protein -
HGN31_RS16130 31099..31563 - 465 WP_168784085.1 hypothetical protein -
HGN31_RS16135 31783..32010 + 228 WP_168784086.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
HGN31_RS16140 32000..32398 + 399 WP_168784087.1 PIN domain-containing protein Toxin
HGN31_RS16145 32412..32766 + 355 Protein_33 transposase -
HGN31_RS16150 32952..34121 - 1170 WP_168784088.1 glutathione-dependent formaldehyde dehydrogenase -
HGN31_RS16155 34268..34381 + 114 Protein_35 IS5/IS1182 family transposase -
HGN31_RS16160 34427..34720 - 294 WP_168784089.1 antibiotic biosynthesis monooxygenase -
HGN31_RS16165 34919..35347 - 429 WP_036733463.1 type II toxin-antitoxin system VapC family toxin -
HGN31_RS16170 35344..35565 - 222 WP_036733460.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
HGN31_RS16175 35972..36112 + 141 WP_168784090.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43005 43005
- flank IS/Tn - - 32555..32680 125


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-43)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14273.41 Da        Isoelectric Point: 4.2386

>T154408 WP_168784087.1 NZ_CP051544:32000-32398 [Paracoccus sanguinis]
MSADFLDTNVILYLLDDGPKADRAAEVVASGGTISVQVLNETLANCIRKARMSWHEAAEFLAEVQAVCPVCDLTAEVHRV
GLALGARYGFSVYDAMIVAAALVNGCDRLLSEDMQDGMLVEGRLRIIDPFQV

Download         Length: 399 bp

>T154408 NZ_CP068041:c2067986-2067879 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8399.76 Da        Isoelectric Point: 11.1995

>AT154408 WP_168784086.1 NZ_CP051544:31783-32010 [Paracoccus sanguinis]
MQVAKWGNSLAVRLPAGLVREMGLKEGDRVELTPAEGHLIVRRQPTPAELLDGLRRFRGRLPVADRLCRDAANER

Download         Length: 228 bp

>AT154408 NZ_CP068041:2068034-2068100 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References