Detailed information of TA system TA154407

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 1806975..1807536
• Replicon: chromosome
• Accession: NZ_CP051542
• Organism: Paracoccus sanguinis strain OM2164

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HGN31_RS08580
• Protein ID: WP_168782941.1
• Coordinates: 1806975..1807250 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1H2UD74
• Locus tag: HGN31_RS08585
• Protein ID: WP_036734747.1
• Coordinates: 1807237..1807536 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGN31_RS08560	1802216..1803118	-	903	WP_168782939.1	rhodanese-related sulfurtransferase	-
HGN31_RS08565	1803160..1804821	-	1662	WP_211096276.1	anion permease	-
HGN31_RS08570	1805010..1805606	+	597	WP_168782940.1	bifunctional nicotinamidase/pyrazinamidase	-
HGN31_RS08575	1805603..1806925	+	1323	WP_081962786.1	nicotinate phosphoribosyltransferase	-
HGN31_RS08580	1806975..1807250	-	276	WP_168782941.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
HGN31_RS08585	1807237..1807536	-	300	WP_036734747.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HGN31_RS08590	1807663..1808127	-	465	WP_036703609.1	Lrp/AsnC family transcriptional regulator	-
HGN31_RS08595	1808263..1809381	+	1119	WP_168782942.1	alanine dehydrogenase	-
HGN31_RS08600	1809457..1809933	-	477	WP_052171927.1	large conductance mechanosensitive channel protein MscL	-
HGN31_RS08605	1810038..1810751	+	714	WP_168782943.1	glutathione S-transferase N-terminal domain-containing protein	-
HGN31_RS08610	1810872..1811258	+	387	WP_168782944.1	CopG family transcriptional regulator	-
HGN31_RS08615	1811283..1812500	+	1218	WP_168782945.1	PHB depolymerase family esterase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-55)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10536.26 Da
• Isoelectric Point: 11.5078

>T154407 WP_168782941.1 NZ_CP051542:c1807250-1806975 [Paracoccus sanguinis]
VPPVEWSLAARADLIRIVDYVSDHSLPAAEALRDALRAKIDRLPERPRAYRKGRVAGTREMVVGRHYVVVYRETPQAIRI
LRVLHTSRRWP

Nucleotide

• Length: 276 bp

>T154407 NZ_CP068041:c1155069-1154851 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10623.15 Da
• Isoelectric Point: 6.4668

>AT154407 WP_036734747.1 NZ_CP051542:c1807536-1807237 [Paracoccus sanguinis]
MPRQSTMLHVRVDERLKAEASATLAAVGLSVSDAVRIMLTRVVSEGGLPAGLATDPAAYDAWFRTKVQEALDDPRPALPH
DGVMAETDDLIARKRRAAG

Nucleotide

• Length: 300 bp

>AT154407 NZ_CP068041:c1155469-1155095 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A1H2UD74