Detailed information of TA system TA154406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 939724..940348
• Replicon: chromosome
• Accession: NZ_CP051541
• Organism: Helicobacter pylori strain LIM-001

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H8H8H6
• Locus tag: HG574_RS04460
• Protein ID: WP_013356424.1
• Coordinates: 939724..939990 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HG574_RS04465
• Protein ID: WP_202144474.1
• Coordinates: 939971..940348 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG574_RS04425	935288..936055	-	768	WP_000242348.1	ABC transporter ATP-binding protein	-
HG574_RS04430	936055..937035	-	981	WP_000921454.1	iron ABC transporter permease	-
HG574_RS04435	937028..937882	-	855	WP_202144473.1	SDR family oxidoreductase	-
HG574_RS04440	938022..938546	+	525	WP_001135628.1	acyl-CoA thioesterase	-
HG574_RS04445	938742..939027	-	286	Protein_871	endoribonuclease VapD	-
HG574_RS04450	939150..939380	+	231	WP_000269326.1	hypothetical protein	-
HG574_RS04455	939415..939645	-	231	WP_001872823.1	hypothetical protein	-
HG574_RS04460	939724..939990	-	267	WP_013356424.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HG574_RS04465	939971..940348	-	378	WP_202144474.1	hypothetical protein	Antitoxin
HG574_RS04470	941487..943706	-	2220	WP_202144475.1	outer membrane beta-barrel protein	-
HG574_RS04485	944144..944659	+	516	WP_202144476.1	hypothetical protein	-
HG574_RS04490	944737..944919	-	183	Protein_878	hypothetical protein	-
HG574_RS04495	945007..945189	-	183	Protein_879	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (2-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10390.29 Da
• Isoelectric Point: 9.6286

>T154406 WP_013356424.1 NZ_CP051541:c939990-939724 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILTLRKKEPLDPRFQDHALKGKWKPFRECHIKSDILLVYLVKDDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T154406 NZ_CP068041:902758-903156 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14710.51 Da
• Isoelectric Point: 6.4787

>AT154406 WP_202144474.1 NZ_CP051541:c940348-939971 [Helicobacter pylori]
MPNTTAEKDYTKYSEKQLVNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHETPNIQTQQAMRDADNKETDLFVEDFSSYSNERKKALGVEAQS

Nucleotide

• Length: 378 bp

>AT154406 NZ_CP068041:902462-902755 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: H8H8H6