Detailed information of TA system TA154404

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapD-relB/-
• Location: 925645..926293
• Replicon: chromosome
• Accession: NZ_CP051540
• Organism: Helicobacter pylori strain LIM-002

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: U4R912
• Locus tag: HG575_RS04350
• Protein ID: WP_000271047.1
• Coordinates: 925645..925929 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HG575_RS04355
• Protein ID: WP_202247488.1
• Coordinates: 925910..926293 (-)
• Length: 128 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG575_RS04330	922183..922950	-	768	WP_202247482.1	ABC transporter ATP-binding protein	-
HG575_RS04335	922950..923930	-	981	WP_202247484.1	iron ABC transporter permease	-
HG575_RS04340	923923..924786	-	864	WP_202247486.1	SDR family oxidoreductase	-
HG575_RS04345	924926..925450	+	525	WP_001135611.1	acyl-CoA thioesterase	-
HG575_RS04350	925645..925929	-	285	WP_000271047.1	endoribonuclease VapD	Toxin
HG575_RS04355	925910..926293	-	384	WP_202247488.1	hypothetical protein	Antitoxin
HG575_RS04360	927121..929253	-	2133	WP_202247490.1	outer membrane beta-barrel protein	-
HG575_RS04375	929626..930243	+	618	WP_202247492.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11116.63 Da
• Isoelectric Point: 4.8896

>T154404 WP_000271047.1 NZ_CP051540:c925929-925645 [Helicobacter pylori]
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFENTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS

Nucleotide

• Length: 285 bp

>T154404 NZ_CP068041:559498-559785 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 128 a.a.
• Molecular weight: 14873.91 Da
• Isoelectric Point: 5.9866

>AT154404 WP_202247488.1 NZ_CP051540:c926293-925910 [Helicobacter pylori]
MPNTTAEKDYTKYSEKQLFNLMNKKEQEIEKLKRDRAYLEKKMAKELEKKDKGFTIKLEELNKILQEINKRANDCCFGHE
IPNLETQQAMRDVVNGVNLTQIDSLDDLTNELKRENNKGFENVCSSV

Nucleotide

• Length: 384 bp

>AT154404 NZ_CP068041:559772-560074 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Toxin

• AlphaFold DB: U4R912