Detailed information of TA system TA154403

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1539835..1541026
• Replicon: chromosome
• Accession: NZ_CP051539
• Organism: Helicobacter pylori strain LIM-003

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HG576_RS07290
• Protein ID: WP_078264849.1
• Coordinates: 1539835..1540599 (-)
• Length: 255 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: HG576_RS07295
• Protein ID: WP_078240921.1
• Coordinates: 1540589..1541026 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG576_RS07280	1537168..1538328	+	1161	WP_202138842.1	L-seryl-tRNA(Sec) selenium transferase	-
HG576_RS07285	1538421..1539608	+	1188	WP_202138843.1	transcription termination/antitermination protein NusA	-
HG576_RS07290	1539835..1540599	-	765	WP_078264849.1	hypothetical protein	Toxin
HG576_RS07295	1540589..1541026	-	438	WP_078240921.1	SocA family protein	Antitoxin
HG576_RS07300	1541545..1542075	-	531	WP_202137945.1	hypothetical protein	-
HG576_RS07305	1542076..1545879	-	3804	WP_202138844.1	class I SAM-dependent DNA methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 255 a.a.
• Molecular weight: 29858.81 Da
• Isoelectric Point: 7.2151

>T154403 WP_078264849.1 NZ_CP051539:c1540599-1539835 [Helicobacter pylori]
METKEEDRDKKLEEMIVLLCEKGDLSSQTDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMTLTQNIRTLKEIQ
DNKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLKDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFV
GGLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEEKDKQENFFKKPIFWFNLMVTILFVIGFC
GELHIIQRLDSKYF

Nucleotide

• Length: 765 bp

>T154403 NZ_CP068041:184199-184306 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17187.31 Da
• Isoelectric Point: 5.7154

>AT154403 WP_078240921.1 NZ_CP051539:c1541026-1540589 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDEHLVSDDFEAWKYGPVAREVYYKYRNYGANPIDKPKEETL
SQNLRKDELETINCSIEKCNEKSYWDLVKESHKEDGAWHKSFKEDGKEIISKDLIKQEAKQTNGN

Nucleotide

• Length: 438 bp

>AT154403 NZ_CP068041:c184151-184085 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT