Detailed information of TA system TA154397

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 328328..328899
• Replicon: chromosome
• Accession: NZ_CP051537
• Organism: Helicobacter pylori strain LIM-005

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HG578_RS01550
• Protein ID: WP_187924483.1
• Coordinates: 328627..328899 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: T2SRI6
• Locus tag: HG578_RS01545
• Protein ID: WP_021172939.1
• Coordinates: 328328..328579 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG578_RS01515	323476..324594	-	1119	WP_021174908.1	site-specific DNA-methyltransferase	-
HG578_RS01520	324690..325067	+	378	WP_202134938.1	hypothetical protein	-
HG578_RS01525	325067..326032	+	966	WP_187924602.1	GTP-binding protein	-
HG578_RS01530	326038..327183	-	1146	WP_187924603.1	YbfB/YjiJ family MFS transporter	-
HG578_RS01535	327678..327947	-	270	Protein_296	virulence associated protein VapD	-
HG578_RS01540	328085..328315	+	231	WP_080119075.1	hypothetical protein	-
HG578_RS01545	328328..328579	-	252	WP_021172939.1	hypothetical protein	Antitoxin
HG578_RS01550	328627..328899	-	273	WP_187924483.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HG578_RS01555	328913..329203	-	291	WP_187915350.1	hypothetical protein	-
HG578_RS01560	330128..332356	-	2229	WP_202134939.1	outer membrane beta-barrel protein	-
HG578_RS01565	332651..333406	-	756	WP_187834744.1	HugZ family heme oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10455.36 Da
• Isoelectric Point: 8.4839

>T154397 WP_187924483.1 NZ_CP051537:c328899-328627 [Helicobacter pylori]
MLMIETSKKFDKDLKILVKNGFDLKLLYEVVGNLATEQPLEPKYKDHPLKGALKDFRECYLKPDLLLVCQIKKQENTLFL
VRLGSHSESF

Nucleotide

• Length: 273 bp

>T154397 NZ_CP068039:c38783-38496 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGGCTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGTGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGCGAAAGAATGAGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9619.62 Da
• Isoelectric Point: 4.2465

>AT154397 WP_021172939.1 NZ_CP051537:c328579-328328 [Helicobacter pylori]
MPNTTNKDYTKYSQRQLFNLINQLEQEISQAFDDKRGCCLGHEIPNLETQQAMREALNGENLEVIEDFSAWANEIKKEVN
AEN

Nucleotide

• Length: 252 bp

>AT154397 NZ_CP068039:c39031-38780 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAACCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TTGATGCCCTAGACGATCAGGAGTTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGATCTGGAT
AAATACCTATGA

Structures

Antitoxin

• AlphaFold DB: T2SRI6