Detailed information of TA system TA154396

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1549488..1550649
• Replicon: chromosome
• Accession: NZ_CP051536
• Organism: Helicobacter pylori strain LIM-007

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HG580_RS07420
• Protein ID: WP_202145817.1
• Coordinates: 1549488..1550222 (-)
• Length: 245 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: HG580_RS07425
• Protein ID: WP_202145818.1
• Coordinates: 1550212..1550649 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG580_RS07400	1544811..1545998	+	1188	WP_202145814.1	transcription termination/antitermination protein NusA	-
HG580_RS07405	1546417..1547634	-	1218	WP_202145815.1	modification methylase	-
HG580_RS07410	1547636..1548334	-	699	WP_202146413.1	hypothetical protein	-
HG580_RS07415	1548426..1549445	-	1020	WP_202145816.1	IS1595 family transposase	-
HG580_RS07420	1549488..1550222	-	735	WP_202145817.1	hypothetical protein	Toxin
HG580_RS07425	1550212..1550649	-	438	WP_202145818.1	SocA family protein	Antitoxin
HG580_RS07430	1550869..1552495	-	1627	Protein_1441	RNA-directed DNA polymerase	-
HG580_RS07435	1552518..1553030	-	513	WP_202145819.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1548426..1549445	1019

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 245 a.a.
• Molecular weight: 28700.58 Da
• Isoelectric Point: 7.7261

>T154396 WP_202145817.1 NZ_CP051536:c1550222-1549488 [Helicobacter pylori]
METKEEDKDKKLEEIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMTLTQNIKTLKEIQ
NNREVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIRLDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEEKDKQENFKKPIFWFNLMVTILWLCMKNVL
LFKV

Nucleotide

• Length: 735 bp

>T154396 NZ_CP068039:17558-17839 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGATAGCCAGTGGGGAAAAGTG
TATATCCTGCGTGTATTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17300.42 Da
• Isoelectric Point: 6.1265

>AT154396 WP_202145818.1 NZ_CP051536:c1550649-1550212 [Helicobacter pylori]
MVNTLELAKYILKHSDKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINRSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT154396 NZ_CP068039:17292-17561 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCTGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
CGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCTGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGATAAATGA