Detailed information of TA system TA154394

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 896641..897274
• Replicon: chromosome
• Accession: NZ_CP051536
• Organism: Helicobacter pylori strain LIM-007

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HG580_RS04265
• Protein ID: WP_202145426.1
• Coordinates: 896641..896907 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HG580_RS04270
• Protein ID: WP_202145427.1
• Coordinates: 896888..897274 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG580_RS04245	893288..894055	-	768	WP_048944938.1	ABC transporter ATP-binding protein	-
HG580_RS04250	894055..895035	-	981	WP_202145423.1	iron ABC transporter permease	-
HG580_RS04255	895028..895870	-	843	WP_202145424.1	SDR family oxidoreductase	-
HG580_RS04260	896011..896535	+	525	WP_202145425.1	acyl-CoA thioesterase	-
HG580_RS04265	896641..896907	-	267	WP_202145426.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HG580_RS04270	896888..897274	-	387	WP_202145427.1	hypothetical protein	Antitoxin
HG580_RS04275	897682..899931	-	2250	WP_202145428.1	outer membrane beta-barrel protein	-
HG580_RS04290	900977..901243	-	267	WP_202145429.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10331.27 Da
• Isoelectric Point: 9.9212

>T154394 WP_202145426.1 NZ_CP051536:c896907-896641 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLNKIILSLRKKEPLDPQFKDHALKGKWKPFRECHIKADILLVYLVKDDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T154394 NZ_CP068035:5131078-5131455 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAA
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14948.84 Da
• Isoelectric Point: 5.3472

>AT154394 WP_202145427.1 NZ_CP051536:c897274-896888 [Helicobacter pylori]
MPNSPTKKDYTQYSEKQLFNLINQLEQKIKKMQNDRASFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCL
GHEIPNLETQQAMRDALNGENLETDLIVEDFSSYSDERKKALGVKTQS

Nucleotide

• Length: 387 bp

>AT154394 NZ_CP068035:5130620-5130988 [Escherichia coli]
GTGTCAGACACATTCTCCGGAACAACTCATCCCGATGATAACAACAGCCGCCCCTGGTGGGGACTGCCCTGCACCGTGAC
ACCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTACATTACCTTGCAGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCCGAAACGAAAAAGTAA