Detailed information of TA system TA154392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ(toxin)
• Location: 925429..926053
• Replicon: chromosome
• Accession: NZ_CP051534
• Organism: Helicobacter pylori strain LIM-009

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: HG582_RS04365
• Protein ID: WP_202143538.1
• Coordinates: 925429..925695 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HG582_RS04370
• Protein ID: WP_202143539.1
• Coordinates: 925682..926053 (-)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG582_RS04340	920883..921983	-	1101	WP_202144386.1	glycosyltransferase family 8 protein	-
HG582_RS04345	922063..922830	-	768	WP_000242349.1	ABC transporter ATP-binding protein	-
HG582_RS04350	922830..923810	-	981	WP_000921470.1	iron ABC transporter permease	-
HG582_RS04355	923803..924657	-	855	WP_202143537.1	SDR family oxidoreductase	-
HG582_RS04360	924797..925321	+	525	WP_001135623.1	acyl-CoA thioesterase	-
HG582_RS04365	925429..925695	-	267	WP_202143538.1	type II toxin-antitoxin system YafQ family toxin	Toxin
HG582_RS04370	925682..926053	-	372	WP_202143539.1	hypothetical protein	Antitoxin
HG582_RS04375	926454..928697	-	2244	WP_202143540.1	outer membrane beta-barrel protein	-
HG582_RS04390	929052..929678	+	627	WP_202143541.1	hypothetical protein	-
HG582_RS04395	929629..930741	-	1113	WP_202143542.1	hydrogenase formation protein HypD	-
HG582_RS04400	930744..930980	-	237	WP_078284132.1	HypC/HybG/HupF family hydrogenase formation chaperone	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (1-88)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10421.46 Da
• Isoelectric Point: 10.3223

>T154392 WP_202143538.1 NZ_CP051534:c925695-925429 [Helicobacter pylori]
MLKIKHHVLYKKDFKKLVKNGFDDSVLNKVILTLRKKEPLSPQFQDHALKGKWKPFRECHIKPDVLLVYLVKDDELILLR
LGSHSELF

Nucleotide

• Length: 267 bp

>T154392 NZ_CP068035:4519627-4520091 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 14667.49 Da
• Isoelectric Point: 5.8183

>AT154392 WP_202143539.1 NZ_CP051534:c926053-925682 [Helicobacter pylori]
MPNTTAEKDYTQYSQRQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
RHEIPNIQTQQAMRDALNGENLETIEDFSAWANEIKKEVNAEN

Nucleotide

• Length: 372 bp

>AT154392 NZ_CP068035:4519292-4519627 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGGTGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA