Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ(toxin)
Location 1020832..1021456 Replicon chromosome
Accession NZ_CP051533
Organism Helicobacter pylori strain LIM-010

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HG583_RS04815 Protein ID WP_202142601.1
Coordinates 1020832..1021098 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HG583_RS04820 Protein ID WP_202142602.1
Coordinates 1021079..1021456 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HG583_RS04780 1016431..1017198 - 768 WP_000242349.1 ABC transporter ATP-binding protein -
HG583_RS04785 1017198..1018178 - 981 WP_000921454.1 iron ABC transporter permease -
HG583_RS04790 1018171..1019025 - 855 WP_202142599.1 SDR family oxidoreductase -
HG583_RS04795 1019165..1019689 + 525 WP_001135624.1 acyl-CoA thioesterase -
HG583_RS04800 1019883..1020152 - 270 Protein_942 virulence associated protein VapD -
HG583_RS04805 1020290..1020520 + 231 WP_080025421.1 hypothetical protein -
HG583_RS04810 1020533..1020784 - 252 WP_202142600.1 hypothetical protein -
HG583_RS04815 1020832..1021098 - 267 WP_202142601.1 type II toxin-antitoxin system YafQ family toxin Toxin
HG583_RS04820 1021079..1021456 - 378 WP_202142602.1 hypothetical protein Antitoxin
HG583_RS04825 1022426..1024570 - 2145 WP_202143449.1 outer membrane beta-barrel protein -
HG583_RS04840 1025532..1025804 - 273 WP_202142603.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10391.23 Da        Isoelectric Point: 8.0603

>T154391 WP_202142601.1 NZ_CP051533:c1021098-1020832 [Helicobacter pylori]
VLKLNLKKSFQKDFDKLLLNGFDDSVLKEVILTLRKKEPLDPRFQDHALKGKWKPFRECHIKSDILLVYLVEDDELILLR
LGSHSELF

Download         Length: 267 bp

>T154391 NZ_CP068035:c4387200-4386904 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14758.51 Da        Isoelectric Point: 5.8214

>AT154391 WP_202142602.1 NZ_CP051533:c1021456-1021079 [Helicobacter pylori]
MPNTTAEKDYTQYSEKQLFNLIHQLERKIKKMQNDRVSFKEKMAKELEKRDQNFKDKIDALNELLQKISQAFDDKRDCCF
GHETPNIQTQQAMRDADNKETDLFVEDFSSYSNERKKALGVEAQS

Download         Length: 378 bp

>AT154391 NZ_CP068035:c4386902-4386507 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References