154385

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 34040..34611 Replicon plasmid pSBP2_mcr4
Accession NZ_CP051531
Organism Shewanella baltica strain 11FHM2

Toxin (Protein)


Gene name parE Uniprot ID Q07XG2
Locus tag HHE93_RS22955 Protein ID WP_011638897.1
Coordinates 34040..34351 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q07XG1
Locus tag HHE93_RS22960 Protein ID WP_011638898.1
Coordinates 34351..34611 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HHE93_RS22940 (HHE93_23030) 29365..29916 - 552 WP_058689192.1 recombinase family protein -
HHE93_RS22945 (HHE93_23035) 30083..30880 + 798 Protein_32 DUF4158 domain-containing protein -
HHE93_RS22950 (HHE93_23040) 30930..34016 - 3087 WP_011638896.1 Tn3 family transposase -
HHE93_RS22955 (HHE93_23045) 34040..34351 - 312 WP_011638897.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HHE93_RS22960 (HHE93_23050) 34351..34611 - 261 WP_011638898.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HHE93_RS22965 (HHE93_23055) 34879..35382 + 504 Protein_36 Tn3 family transposase -
HHE93_RS22970 (HHE93_23060) 35421..35828 + 408 WP_254155576.1 Cd(II)/Pb(II)-responsive transcriptional regulator -
HHE93_RS22975 (HHE93_23065) 35860..36768 + 909 WP_011919296.1 cation diffusion facilitator family transporter -
HHE93_RS22980 (HHE93_23070) 36770..37096 + 327 WP_008224334.1 YnfA family protein -
HHE93_RS22985 (HHE93_23075) 37240..37587 - 348 WP_058689194.1 mercuric transporter MerT family protein -
HHE93_RS22990 (HHE93_23080) 37665..38066 - 402 WP_069455590.1 Hg(II)-responsive transcriptional regulator -
HHE93_RS22995 (HHE93_23085) 38174..38347 + 174 Protein_42 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-4.3 - 1..86727 86727


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-62)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11830.64 Da        Isoelectric Point: 8.5341

>T154385 WP_011638897.1 NZ_CP051531:c34351-34040 [Shewanella baltica]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T154385 NZ_CP068035:c3175875-3175624 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9330.74 Da        Isoelectric Point: 6.4546

>AT154385 WP_011638898.1 NZ_CP051531:c34611-34351 [Shewanella baltica]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT154385 NZ_CP068035:c3175627-3175373 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A883CRN5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8ZVH1

References