Detailed information of TA system TA154383

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 2550337..2550893
• Replicon: chromosome
• Accession: NZ_CP051523
• Organism: Treponema denticola strain OMZ 852

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q73QZ0
• Locus tag: E4N84_RS12210
• Protein ID: WP_002676650.1
• Coordinates: 2550337..2550618 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QZ1
• Locus tag: E4N84_RS12215
• Protein ID: WP_002676649.1
• Coordinates: 2550615..2550893 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N84_RS12195 (E4N84_12255)	2545548..2547377	+	1830	WP_253731057.1	signal peptide peptidase SppA	-
E4N84_RS12200 (E4N84_12260)	2547416..2548522	+	1107	WP_002666350.1	redox-regulated ATPase YchF	-
E4N84_RS12205 (E4N84_12265)	2548704..2550260	-	1557	WP_002681251.1	hypothetical protein	-
E4N84_RS12210 (E4N84_12270)	2550337..2550618	-	282	WP_002676650.1	type II toxin-antitoxin system YafQ family toxin	Toxin
E4N84_RS12215 (E4N84_12275)	2550615..2550893	-	279	WP_002676649.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N84_RS12220 (E4N84_12280)	2550966..2551769	-	804	WP_253681138.1	class I SAM-dependent methyltransferase	-
E4N84_RS12225 (E4N84_12285)	2551843..2553273	-	1431	WP_002692277.1	leucyl aminopeptidase	-
E4N84_RS12230 (E4N84_12290)	2553616..2554035	-	420	WP_253731058.1	(deoxy)nucleoside triphosphate pyrophosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10774.68 Da
• Isoelectric Point: 10.2467

>T154383 WP_002676650.1 NZ_CP051523:c2550618-2550337 [Treponema denticola]
MIYQLKKTSQFKASVKLAKKRGLNINLLEGIIEKLRTDTPLGVKHKNHQLSGQFKGIWECHIQPDWLLLYLKEENNLVMT
LVDTGTHSDIFKK

Nucleotide

• Length: 282 bp

>T154383 NZ_CP068035:3163731-3164105 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10223.83 Da
• Isoelectric Point: 6.2705

>AT154383 WP_002676649.1 NZ_CP051523:c2550893-2550615 [Treponema denticola]
MSTAVLQTRVDSQIKKEADDLFNALGIDTTTAIRLFLKQAINQQKIPFEILPPQKEFSPSVLAAIKEARQISCDASVKQY
KTAKELLADCEV

Nucleotide

• Length: 279 bp

>AT154383 NZ_CP068035:3163337-3163642 [Escherichia coli]
CTGCCCTGTACCGTGACGCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGC
CGGTATCAGAGGCCTGTTCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAAC
TCATGCTCACCAGCGGTGAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCC
GATACCCTCAGCAGTTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Toxin

• AlphaFold DB: Q73QZ0

Antitoxin

• AlphaFold DB: Q73QZ1