Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-DinJ
Location 2202064..2202589 Replicon chromosome
Accession NZ_CP051523
Organism Treponema denticola strain OMZ 852

Toxin (Protein)


Gene name relB Uniprot ID M2CK18
Locus tag E4N84_RS10535 Protein ID WP_002685473.1
Coordinates 2202326..2202589 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q73PY2
Locus tag E4N84_RS10530 Protein ID WP_002677040.1
Coordinates 2202064..2202321 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N84_RS10525 (E4N84_10585) 2200470..2201738 - 1269 WP_253690051.1 OmpA family protein -
E4N84_RS10530 (E4N84_10590) 2202064..2202321 + 258 WP_002677040.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
E4N84_RS10535 (E4N84_10595) 2202326..2202589 + 264 WP_002685473.1 Txe/YoeB family addiction module toxin Toxin
E4N84_RS10540 (E4N84_10600) 2202704..2202982 + 279 WP_002669909.1 antitoxin -
E4N84_RS10545 (E4N84_10605) 2202966..2203373 + 408 WP_147623860.1 type II toxin-antitoxin system VapC family toxin -
E4N84_RS10550 (E4N84_10615) 2203595..2203834 + 240 WP_002685472.1 hypothetical protein -
E4N84_RS10555 (E4N84_10620) 2203834..2204238 + 405 WP_002692716.1 type II toxin-antitoxin system VapC family toxin -
E4N84_RS10560 (E4N84_10625) 2204254..2205159 + 906 WP_002692714.1 YafY family protein -
E4N84_RS10565 (E4N84_10630) 2205236..2205748 + 513 WP_002669904.1 ClbS/DfsB family four-helix bundle protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-63)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10391.93 Da        Isoelectric Point: 9.7704

>T154381 WP_002685473.1 NZ_CP051523:2202326-2202589 [Treponema denticola]
MIKAWDEDAWIDYVYWQTEDKKTLKRINMLIKDIERNGHNGLGSPEPLKGNLSGFWSRRIDKKNRLVYRIADNVIQIIQC
RTHYGEK

Download         Length: 264 bp

>T154381 NZ_CP068035:2769856-2771178 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGAATGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9866.39 Da        Isoelectric Point: 9.5364

>AT154381 WP_002677040.1 NZ_CP051523:2202064-2202321 [Treponema denticola]
MAQINVNIRMDSEVKQEAEQLFDSLGMNMTTAFNIFIRQSLRIGGIPFKIISDERGFYNKYNQKKLHAAAKRMNEGKYIV
HDIVE

Download         Length: 258 bp

>AT154381 NZ_CP068035:2769590-2769856 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M2CK18

Antitoxin

Source ID Structure
AlphaFold DB Q73PY2

References