Detailed information of TA system TA154380

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 615168..615753
• Replicon: chromosome
• Accession: NZ_CP051523
• Organism: Treponema denticola strain OMZ 852

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: E9S222
• Locus tag: E4N84_RS02905
• Protein ID: WP_002668014.1
• Coordinates: 615496..615753 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q73KK4
• Locus tag: E4N84_RS02900
• Protein ID: WP_002668012.1
• Coordinates: 615168..615503 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N84_RS02885 (E4N84_02910)	610628..611839	+	1212	WP_253731483.1	substrate-binding domain-containing protein	-
E4N84_RS02890 (E4N84_02915)	611950..613443	+	1494	WP_253731484.1	sugar ABC transporter ATP-binding protein	-
E4N84_RS02895 (E4N84_02920)	613468..615162	+	1695	WP_253731485.1	galactoside ABC transporter permease	-
E4N84_RS02900 (E4N84_02925)	615168..615503	-	336	WP_002668012.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
E4N84_RS02905 (E4N84_02930)	615496..615753	-	258	WP_002668014.1	type II toxin-antitoxin system HicA family toxin	Toxin
E4N84_RS02910 (E4N84_02935)	615922..617121	+	1200	WP_253731486.1	galactokinase	-
E4N84_RS02915 (E4N84_02940)	617280..617879	+	600	WP_002668018.1	hypothetical protein	-
E4N84_RS02920 (E4N84_02945)	617895..619202	+	1308	WP_253731487.1	right-handed parallel beta-helix repeat-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	609415..610491	1076

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-82)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9589.93 Da
• Isoelectric Point: 10.6118

>T154380 WP_002668014.1 NZ_CP051523:c615753-615496 [Treponema denticola]
VNTKNKKTLENIYKRPVPADIFWTDIESLFISLGAEISEGAGSRIRVKLNNTRAVFHRPHPEKITDKGAVNSVRRFLENA
GVKND

Nucleotide

• Length: 258 bp

>T154380 NZ_CP051523:c615753-615496 [Treponema denticola]
GTGAATACAAAGAATAAAAAAACACTTGAGAACATATATAAACGACCTGTTCCTGCAGATATTTTTTGGACCGATATCGA
AAGCCTATTTATTTCATTAGGTGCGGAAATCTCTGAGGGAGCAGGCTCTCGAATAAGGGTAAAATTGAATAATACACGGG
CTGTTTTTCATAGACCGCATCCTGAAAAAATTACAGATAAGGGAGCTGTTAATTCGGTTAGACGATTTTTAGAAAATGCA
GGAGTAAAAAATGATTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12628.35 Da
• Isoelectric Point: 4.9348

>AT154380 WP_002668012.1 NZ_CP051523:c615503-615168 [Treponema denticola]
MIEYKGYIGKIEYDPEAKILHGDVINTRDVITFQGTSVAEIEKAFIDSVDDYINWCREENIEPEKPYSGKFNIRISPELH
KKIAINAKSLNLSLNTFVEKALQHELASTGI

Nucleotide

• Length: 336 bp

>AT154380 NZ_CP051523:c615503-615168 [Treponema denticola]
ATGATTGAATATAAGGGATATATCGGAAAAATAGAATACGATCCGGAAGCAAAAATTTTACATGGAGATGTCATAAATAC
ACGTGATGTTATTACATTCCAGGGTACAAGCGTAGCAGAAATAGAAAAAGCCTTTATTGACTCTGTCGATGATTACATCA
ACTGGTGCCGAGAAGAAAATATAGAACCCGAAAAACCATATTCGGGAAAATTCAATATACGCATATCACCGGAGCTTCAT
AAAAAAATAGCAATCAACGCAAAAAGCTTAAATCTTTCTTTAAATACTTTTGTTGAAAAAGCATTACAACATGAATTAGC
ATCTACCGGAATATAA

Structures

Toxin

• AlphaFold DB: E9S222

Antitoxin

• AlphaFold DB: Q73KK4