Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1512848..1513518 Replicon chromosome
Accession NZ_CP051522
Organism Treponema denticola strain OMZ 910

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag E4N87_RS07000 Protein ID WP_253716149.1
Coordinates 1513159..1513518 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag E4N87_RS06995 Protein ID WP_253700941.1
Coordinates 1512848..1513162 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N87_RS06970 (E4N87_06970) 1508215..1508592 + 378 WP_253700946.1 polymer-forming cytoskeletal protein -
E4N87_RS06975 (E4N87_06975) 1508582..1509223 + 642 WP_253700945.1 tetratricopeptide repeat protein -
E4N87_RS06980 (E4N87_06980) 1509227..1510633 + 1407 WP_253716146.1 tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))- methylthiotransferase MtaB -
E4N87_RS06985 (E4N87_06985) 1510698..1511840 + 1143 WP_253716147.1 hypothetical protein -
E4N87_RS06990 (E4N87_06990) 1511870..1512811 + 942 WP_253716148.1 DMT family transporter -
E4N87_RS06995 (E4N87_06995) 1512848..1513162 - 315 WP_253700941.1 putative addiction module antidote protein Antitoxin
E4N87_RS07000 (E4N87_07000) 1513159..1513518 - 360 WP_253716149.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
E4N87_RS07005 (E4N87_07005) 1513518..1514801 - 1284 WP_253716150.1 family 1 glycosylhydrolase -
E4N87_RS07010 (E4N87_07010) 1514952..1515491 - 540 WP_253716151.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
E4N87_RS07015 (E4N87_07015) 1515513..1515956 - 444 WP_253700937.1 hypothetical protein -
E4N87_RS07020 (E4N87_07020) 1516169..1516450 + 282 WP_253716152.1 type II toxin-antitoxin system RelE/ParE family toxin -
E4N87_RS07025 (E4N87_07025) 1516464..1516763 + 300 WP_253716153.1 HigA family addiction module antitoxin -
E4N87_RS07030 (E4N87_07030) 1517345..1518097 + 753 WP_253716154.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(30-109)

Antitoxin

Uncharacterized protein HI1420

(2-93)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14060.42 Da        Isoelectric Point: 10.1762

>T154379 WP_253716149.1 NZ_CP051522:c1513518-1513159 [Treponema denticola]
MNYNRLDSLLFLNYNIDMRTIKKTEVFDTWLSKLKDEKGKAKITDRIMRLKRGNKGDHRIIDKDIYELRIHFGPGYRIYC
TDKNNEIILLLIAGDKSTQPKDIKKAQQMIKLLEQGDTK

Download         Length: 360 bp

>T154379 NZ_CP068035:c2357141-2356947 [Escherichia coli]
ATGCGGTATGAAAAAGTCAAACCATGCCCTTTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
CGCGAAGTGTAACGGATGCGAATCCCGAACCGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGCAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11790.35 Da        Isoelectric Point: 5.1199

>AT154379 WP_253700941.1 NZ_CP051522:c1513162-1512848 [Treponema denticola]
MKITDFDPADYLNTKEAMIEYLNEALKTSIEDNTPEHFTEALGDITRAQGFTNVAKHTDLNREHLYRSLSKKGNPTFSTI
LKLLNFLGLEINIIDPQTAKPAYC

Download         Length: 315 bp

>AT154379 NZ_CP068035:2356770-2356948 [Escherichia coli]
GACGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAATTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References