Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicA-relB/HicA-dnstrm_HI1420
Location 1098865..1099462 Replicon chromosome
Accession NZ_CP051522
Organism Treponema denticola strain OMZ 910

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag E4N87_RS05125 Protein ID WP_253718087.1
Coordinates 1098865..1099062 (-) Length 66 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag E4N87_RS05130 Protein ID WP_253718089.1
Coordinates 1099148..1099462 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N87_RS05105 (E4N87_05100) 1094808..1096409 + 1602 WP_253718083.1 5'-nucleotidase C-terminal domain-containing protein -
E4N87_RS05110 (E4N87_05105) 1096524..1097705 + 1182 WP_253718084.1 YibE/F family protein -
E4N87_RS05115 (E4N87_05110) 1097767..1098417 - 651 WP_253718085.1 C39 family peptidase -
E4N87_RS05120 (E4N87_05115) 1098439..1098855 - 417 WP_253718086.1 type II toxin-antitoxin system HicB family antitoxin -
E4N87_RS05125 (E4N87_05120) 1098865..1099062 - 198 WP_253718087.1 type II toxin-antitoxin system HicA family toxin Toxin
E4N87_RS05130 (E4N87_05125) 1099148..1099462 - 315 WP_253718089.1 putative addiction module antidote protein Antitoxin
E4N87_RS05135 (E4N87_05130) 1099478..1100740 - 1263 WP_253718090.1 uracil permease -
E4N87_RS05140 (E4N87_05135) 1100886..1101632 - 747 WP_253718091.1 DUF368 domain-containing protein -
E4N87_RS05145 (E4N87_05140) 1101709..1102767 + 1059 WP_253718092.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
E4N87_RS05150 (E4N87_05145) 1102787..1103500 + 714 WP_253718093.1 tRNA threonylcarbamoyladenosine dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin

Cro/C1-type helix-turn-helix domain

(51-92)


Sequences

Toxin        


Download         Length: 66 a.a.        Molecular weight: 7475.73 Da        Isoelectric Point: 10.6290

>T154377 WP_253718087.1 NZ_CP051522:c1099062-1098865 [Treponema denticola]
MKSYTSREVIKILQNDGWYEVAVVGSHHQFKHSIKKGRVTVKHPDKDIPIATLKTIEKQSGIKFK

Download         Length: 198 bp

>T154377 NZ_CP068035:c2217435-2217328 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11721.62 Da        Isoelectric Point: 8.4209

>AT154377 WP_253718089.1 NZ_CP051522:c1099462-1099148 [Treponema denticola]
MKISKWDAADYLRTRKDIAIYLDEILKIAREDNTPELFIEALGDVTRAQGMADLAKTIDVSRESLYKSLSKKGNPSFSTI
FKVLEFLNLEISIAAPKTLKQVSI

Download         Length: 315 bp

>AT154377 NZ_CP068035:2217488-2217549 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References