Detailed information of TA system TA154375

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 597159..597709
• Replicon: chromosome
• Accession: NZ_CP051522
• Organism: Treponema denticola strain OMZ 910

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: E4N87_RS02740
• Protein ID: WP_253717543.1
• Coordinates: 597428..597709 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q73QD7
• Locus tag: E4N87_RS02735
• Protein ID: WP_002665927.1
• Coordinates: 597159..597431 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E4N87_RS02695 (E4N87_02690)	593101..593424	+	324	WP_002685254.1	hypothetical protein	-
E4N87_RS02700 (E4N87_02695)	593532..594338	+	807	WP_010693405.1	DUF4261 domain-containing protein	-
E4N87_RS02705 (E4N87_02700)	594415..594573	+	159	WP_080648458.1	hypothetical protein	-
E4N87_RS02710 (E4N87_02705)	594625..594774	+	150	WP_253688683.1	hypothetical protein	-
E4N87_RS02715 (E4N87_02710)	594776..595447	+	672	WP_253717541.1	hypothetical protein	-
E4N87_RS02720 (E4N87_02715)	595503..596072	+	570	WP_253717542.1	hypothetical protein	-
E4N87_RS02725 (E4N87_02720)	596117..596833	+	717	WP_253682847.1	hypothetical protein	-
E4N87_RS02730 (E4N87_02725)	596884..597093	+	210	WP_002687090.1	hypothetical protein	-
E4N87_RS02735 (E4N87_02730)	597159..597431	+	273	WP_002665927.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
E4N87_RS02740 (E4N87_02735)	597428..597709	+	282	WP_253717543.1	type II toxin-antitoxin system YafQ family toxin	Toxin
E4N87_RS02745 (E4N87_02740)	597784..598407	+	624	WP_253699105.1	hypothetical protein	-
E4N87_RS02750 (E4N87_02745)	598445..599296	+	852	WP_253717544.1	DUF2262 domain-containing protein	-
E4N87_RS02755 (E4N87_02750)	599316..599723	+	408	WP_253717545.1	hypothetical protein	-
E4N87_RS02760 (E4N87_02755)	599816..600880	+	1065	WP_253717546.1	ankyrin repeat domain-containing protein	-
E4N87_RS02765 (E4N87_02760)	601057..602184	+	1128	WP_253717547.1	hypothetical protein	-
E4N87_RS02770 (E4N87_02765)	602301..602681	+	381	WP_253717549.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-89)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 11099.96 Da
• Isoelectric Point: 9.8023

>T154375 WP_253717543.1 NZ_CP051522:597428-597709 [Treponema denticola]
MKYEIKFTNQFKKDIKLAKKQNKNLDKLLKVIDLLSNGEKLEAKYRDHDLSGNYKGTRECHVEPDWLLVYEIRNDVLVLM
LYRLGSHSELFKK

Nucleotide

• Length: 282 bp

>T154375 NZ_CP068035:879661-880599 [Escherichia coli]
ATGGATAAAGGCAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCCACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGGTTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCCGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATCGTTGTATCAAGTCTGGTTGCGACAATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAGATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCAGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTCCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTAGTGGGCTTTTTAACCTA
TACACTAAGTCATCCTCGGCCTATTAATGAAGTTATGTCGCCAAACTGGCAGCCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCTATGATGTTAACTTCGCTGCAAAAA
CATTTCACAGAAAGGGATCATGCTTTCCTTATGTCATTTAAAAGAGGGCAACCTGACTGGGCATTGTTTGATTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAGTTGCAGAACATTTACAAATTGGCAAAGAATCAAGCAAAACATCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10205.78 Da
• Isoelectric Point: 5.1486

>AT154375 WP_002665927.1 NZ_CP051522:597159-597431 [Treponema denticola]
MATTNLNIRTDKEMKERAEAIFFELGLNMTTAINIFLRTTIRENGIPFALKLDIPNAITASAIEEGRKIAYDDTVKKYSN
IDDLRKALEI

Nucleotide

• Length: 273 bp

>AT154375 NZ_CP068035:878877-879668 [Escherichia coli]
ATGTCATCTAAGATAAACTGGCTTGTTGCTCATACTTCTCCTGGAGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
CGTGAGCTACTCGTTGGCTCAGAAGTACGCGCAGAACGGTTGGCTGAAGAAGCTTAGTTCTGGTGTGTACTATCGTCCAA
ATGCGCAAGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTAGATGTGCAATTGGGCGTTTCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCAAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAACCATAAGCTTGAAC
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAGCTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGACGGGATTGGGAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGATCAATCGCATAGATGAAACAAGAATTAAATTGGGTGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACACAATGGATAA

Structures

Antitoxin

• AlphaFold DB: Q73QD7