Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 196314..196948 Replicon chromosome
Accession NZ_CP051522
Organism Treponema denticola strain OMZ 910

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag E4N87_RS00835 Protein ID WP_253699420.1
Coordinates 196544..196948 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag E4N87_RS00830 Protein ID WP_253682979.1
Coordinates 196314..196544 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
E4N87_RS00815 (E4N87_00820) 191908..193242 - 1335 WP_253717128.1 DUF1015 domain-containing protein -
E4N87_RS00820 (E4N87_00825) 193370..194569 + 1200 WP_253699422.1 coenzyme F420-0:L-glutamate ligase -
E4N87_RS00825 (E4N87_00830) 194591..196156 + 1566 WP_253717129.1 LTA synthase family protein -
E4N87_RS00830 (E4N87_00835) 196314..196544 + 231 WP_253682979.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
E4N87_RS00835 (E4N87_00840) 196544..196948 + 405 WP_253699420.1 type II toxin-antitoxin system VapC family toxin Toxin
E4N87_RS00840 (E4N87_00845) 196998..198011 - 1014 WP_253717130.1 tRNA-dihydrouridine synthase family protein -
E4N87_RS00845 (E4N87_00850) 198015..198695 - 681 WP_253699418.1 hypothetical protein -
E4N87_RS00850 (E4N87_00855) 198716..199345 - 630 WP_253717132.1 rhomboid family intramembrane serine protease -
E4N87_RS00855 (E4N87_00860) 199367..200482 - 1116 WP_253717134.1 diguanylate cyclase DgcA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15523.89 Da        Isoelectric Point: 6.9280

>T154373 WP_253699420.1 NZ_CP051522:196544-196948 [Treponema denticola]
MYLLDTNICIFLIKNKNPYLKKKIFNCKKEELFLSSITIAELEYGVSKSQFREKNRHALLDFCSDFTNIIDFTTEDTETY
GMIRAYLENKGIPIGPFDTQIAAQALARNLTVVTNNIREFSRIPGLKVDDWTKE

Download         Length: 405 bp

>T154373 NZ_CP068035:628440-628790 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8755.95 Da        Isoelectric Point: 4.7660

>AT154373 WP_253682979.1 NZ_CP051522:196314-196544 [Treponema denticola]
MICTKVFTSGNSQAVRIPKEFHIDFSELLIKKIGSSIILTPKESNWENLERSLSEFSDDFMTEGRSQPAMQEREVF

Download         Length: 231 bp

>AT154373 NZ_CP068035:628195-628446 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References