Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4382574..4383163 Replicon chromosome
Accession NZ_CP051516
Organism Paraburkholderia aromaticivorans strain AR20-38

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HF916_RS48140 Protein ID WP_168795541.1
Coordinates 4382574..4382756 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HF916_RS48145 Protein ID WP_168795542.1
Coordinates 4382753..4383163 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF916_RS48110 4377681..4378403 - 723 WP_168795536.1 flagellar hook assembly protein FlgD -
HF916_RS48115 4378414..4378839 - 426 WP_012434707.1 flagellar basal body rod protein FlgC -
HF916_RS48120 4378934..4379428 - 495 WP_168795537.1 flagellar basal body rod protein FlgB -
HF916_RS48125 4379646..4381166 + 1521 WP_168795538.1 flagellar basal body P-ring formation protein FlgA -
HF916_RS48130 4381368..4381721 + 354 WP_168795539.1 flagellar biosynthesis anti-sigma factor FlgM -
HF916_RS48135 4381816..4382262 + 447 WP_168795540.1 flagellar protein FlgN -
HF916_RS48140 4382574..4382756 + 183 WP_168795541.1 type II toxin-antitoxin system HicA family toxin Toxin
HF916_RS48145 4382753..4383163 + 411 WP_168795542.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HF916_RS48150 4383223..4383957 - 735 WP_012434714.1 RNA polymerase sigma factor FliA -
HF916_RS48155 4383986..4384855 - 870 WP_168795543.1 AAA family ATPase -
HF916_RS48160 4384848..4386800 - 1953 WP_168795544.1 flagellar biosynthesis protein FlhF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6597.83 Da        Isoelectric Point: 11.7594

>T154372 WP_168795541.1 NZ_CP051516:4382574-4382756 [Paraburkholderia aromaticivorans]
MKSVEVVKLIQAAGWRLVRITGSHHHYRHAARAGLVTIPHPKKDLPPGTLNSILKQAGLK

Download         Length: 183 bp

>T154372 NZ_CP068035:489014-489187 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14809.83 Da        Isoelectric Point: 4.3641

>AT154372 WP_168795542.1 NZ_CP051516:4382753-4383163 [Paraburkholderia aromaticivorans]
MKNLTFPIAIEPGDADHAFGVIVPDIPGCYAAGDTLEEAYANAKEAIEAHLDVLLDEGLPIPGRLTLEEHRRNPDYADFT
WGLVATRNIPALKKAVRINISLPEALVQEIDTYAQARGMSRSAFLALAAEHEMAEV

Download         Length: 411 bp

>AT154372 NZ_CP068035:488690-488986 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References