Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 2421410..2421972 Replicon chromosome
Accession NZ_CP051516
Organism Paraburkholderia aromaticivorans strain AR20-38

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HF916_RS39025 Protein ID WP_168794064.1
Coordinates 2421410..2421658 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HF916_RS39030 Protein ID WP_168794065.1
Coordinates 2421652..2421972 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF916_RS38990 2417052..2417573 - 522 WP_168794059.1 (2Fe-2S)-binding protein -
HF916_RS38995 2417610..2418482 - 873 WP_168794060.1 xanthine dehydrogenase family protein subunit M -
HF916_RS39000 2418620..2418781 + 162 WP_168794061.1 hypothetical protein -
HF916_RS39005 2418843..2419646 + 804 WP_168794062.1 LytTR family transcriptional regulator -
HF916_RS39010 2419687..2420016 - 330 WP_168794063.1 hypothetical protein -
HF916_RS39015 2420237..2420728 + 492 WP_168795795.1 RidA family protein -
HF916_RS39020 2420725..2421189 - 465 WP_168795796.1 hypothetical protein -
HF916_RS39025 2421410..2421658 + 249 WP_168794064.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
HF916_RS39030 2421652..2421972 + 321 WP_168794065.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
HF916_RS39035 2422049..2423389 - 1341 WP_168794066.1 BatD family protein -
HF916_RS39040 2423386..2424978 - 1593 WP_168794067.1 VWA domain-containing protein -
HF916_RS39045 2424968..2426002 - 1035 WP_206002062.1 VWA domain-containing protein -
HF916_RS39050 2426013..2426552 - 540 WP_168794069.1 DUF4381 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(9-47)

Antitoxin

mRNA interferase PemK-like

(1-103)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9021.25 Da        Isoelectric Point: 4.4819

>T154368 WP_168794064.1 NZ_CP051516:2421410-2421658 [Paraburkholderia aromaticivorans]
MKTTIRRMGNSQGVLIPKPVLAQLGLEKEVEMEVENDAIVLRRPRQKAREGWAEASKALAESGDDALLIGDFGNADDAEL
TW

Download         Length: 249 bp

>T154368 NZ_CP068033:c4833079-4832162 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTTCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGAGCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAGTCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11886.11 Da        Isoelectric Point: 10.3997

>AT154368 WP_168794065.1 NZ_CP051516:2421652-2421972 [Paraburkholderia aromaticivorans]
MVVRGEVWLVALDPTLGSEIQKTRPCVVVSPPEMHDHLRTAIVAPMTSKGRPAPYRIPVTFKRKQGLILLDQIRSVDKLR
LVKKEGAIADKAMLDTLRTLQEVFAE

Download         Length: 321 bp

>AT154368 NZ_CP068033:c4833843-4833085 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References