Detailed information of TA system TA154366

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 897400..898434
• Replicon: chromosome
• Accession: NZ_CP051515
• Organism: Paraburkholderia aromaticivorans strain AR20-38

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: HF916_RS15875
• Protein ID: WP_168789854.1
• Coordinates: 897400..897972 (-)
• Length: 191 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: -
• Locus tag: HF916_RS15880
• Protein ID: WP_168789855.1
• Coordinates: 897976..898434 (-)
• Length: 153 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF916_RS15860	892999..894459	-	1461	WP_168789851.1	NADP-dependent succinate-semialdehyde dehydrogenase	-
HF916_RS15865	894470..895753	-	1284	WP_168789852.1	4-aminobutyrate--2-oxoglutarate transaminase	-
HF916_RS15870	895877..897382	+	1506	WP_168789853.1	PLP-dependent aminotransferase family protein	-
HF916_RS15875	897400..897972	-	573	WP_168789854.1	PIN domain-containing protein	Toxin
HF916_RS15880	897976..898434	-	459	WP_168789855.1	helix-turn-helix domain-containing protein	Antitoxin
HF916_RS15885	898535..899371	-	837	WP_168789856.1	DMT family transporter	-
HF916_RS15890	899648..900490	-	843	WP_168789857.1	phosphonate ABC transporter, permease protein PhnE	-
HF916_RS15895	900487..901464	-	978	WP_168789858.1	phosphonate ABC transporter substrate-binding protein	-
HF916_RS15900	901506..902411	-	906	WP_168789859.1	phosphonate ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (8-113)

Antitoxin

• Helix-turn-helix domain, group 17 (83-130)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 21449.60 Da
• Isoelectric Point: 6.0679

>T154366 WP_168789854.1 NZ_CP051515:c897972-897400 [Paraburkholderia aromaticivorans]
MSSHFTAVYDACVLYSQPLRNLLMRLALTDLYRARWTCAIHDEWVRNLIANRPDLDRAKIYRVRELMDTHVRDALVENFE
HLIPAIELPDPTDAHVVAAAVHCGAELIVTFNLRDFPAAALGTFNVTAQHPDDFIADLFDLNQAKVLEAMAEHRKSLKNP
PKSVDEYLDTLARLGLTQTVSAVRPYSIAI

Nucleotide

• Length: 573 bp

>T154366 NZ_CP068033:c4551390-4550857 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTTTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 153 a.a.
• Molecular weight: 17275.63 Da
• Isoelectric Point: 6.7334

>AT154366 WP_168789855.1 NZ_CP051515:c898434-897976 [Paraburkholderia aromaticivorans]
MNTTIHPTPLPSQQEAELARTSSRNLSVVLSSRAETQQFDFKDDRGQTRTVELPTSVVRLMVDVLTEIGQGNAVSIIPIH
AELTTQEAADLLNVSRPYFVQLLEKKEIPFRKVNTHRRVRYEDVMAYKNRIDAQRRKALDELAALSQDMGLE

Nucleotide

• Length: 459 bp

>AT154366 NZ_CP068033:c4551667-4551401 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA