Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 55087..56862 Replicon chromosome
Accession NZ_CP051515
Organism Paraburkholderia aromaticivorans strain AR20-38

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag HF916_RS12035 Protein ID WP_168789185.1
Coordinates 55087..55977 (+) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag HF916_RS12040 Protein ID WP_206001871.1
Coordinates 55978..56862 (+) Length 295 a.a.

Genomic Context

HF916_RS12010HF916_RS12015HF916_RS12020HF916_RS12025HF916_RS12030HF916_RS12035HF916_RS12040HF916_RS12045HF916_RS12050HF916_RS12055HF916_RS12060HF916_RS12005
Location: 51957..52271 (315 bp)
Type: Others
Protein ID: WP_168789180.1
Location: 52273..52584 (312 bp)
Type: Others
Protein ID: WP_168789181.1
Location: 52633..53727 (1095 bp)
Type: Others
Protein ID: WP_168789182.1
Location: 53720..54487 (768 bp)
Type: Others
Protein ID: WP_168789183.1
Location: 54514..55041 (528 bp)
Type: Others
Protein ID: WP_168789184.1
Location: 55087..55977 (891 bp)
Type: Toxin
Protein ID: WP_168789185.1
Location: 55978..56862 (885 bp)
Type: Antitoxin
Protein ID: WP_206001871.1
Location: 56862..57659 (798 bp)
Type: Others
Protein ID: WP_168789186.1
Location: 57652..59310 (1659 bp)
Type: Others
Protein ID: WP_168789187.1
Location: 59303..60133 (831 bp)
Type: Others
Protein ID: WP_168789188.1
Location: 60173..61663 (1491 bp)
Type: Others
Protein ID: WP_168791973.1
Location: 50442..51515 (1074 bp)
Type: Others
Protein ID: WP_168789179.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
HF916_RS1200550442..51515-1074WP_168789179.1porin-
HF916_RS1201051957..52271+315WP_168789180.1non-heme iron oxygenase ferredoxin subunit-
HF916_RS1201552273..52584+312WP_168789181.1hypothetical protein-
HF916_RS1202052633..53727+1095WP_168789182.1aromatic ring-hydroxylating dioxygenase subunit alpha-
HF916_RS1202553720..54487+768WP_168789183.1SDR family oxidoreductase-
HF916_RS1203054514..55041+528WP_168789184.1cupin domain-containing protein-
HF916_RS1203555087..55977+891WP_168789185.1alpha/beta fold hydrolaseToxin
HF916_RS1204055978..56862+885WP_206001871.1helix-turn-helix domain-containing proteinAntitoxin
HF916_RS1204556862..57659+798WP_168789186.1SDR family oxidoreductase-
HF916_RS1205057652..59310+1659WP_168789187.1thiamine pyrophosphate-binding protein-
HF916_RS1205559303..60133+831WP_168789188.1aspartate dehydrogenase-
HF916_RS1206060173..61663+1491WP_168791973.1aldehyde dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-279)

Antitoxin

Transcription regulator IclR, C-terminal

(148-272)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 30987.03 Da        Isoelectric Point: 7.1058

>T154365 WP_168789185.1 NZ_CP051515:55087-55977 [Paraburkholderia aromaticivorans]
MSAVPSVTADQHATLEARLARFPAQQIGLASQRAVSYREVDSADSSALPLVLLHGIGSGAASWVQQFEGLGATRRVLAWD
APGYGASTPVAAESPAAADYATVLKEWLDALGIERCVLLGHSLGAVVAGAFAVTHPQRVAGLLLLSPAGGYGAASADVRN
TKRDQRLAMLNELGPQGLAEKRSTNMLSAHASDEARAWVRWNMSRVIPLGYAQATHLLANADLAGDLARFKGRINVAVGA
DDTITTPEACERLARAAGTQLQVVPRAGHAGYIEAPAAYTAIIDTFCRTSDGPRSQ

Download         Length: 891 bp

>T154365 NZ_CP068033:3933402-3933620 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 295 a.a.        Molecular weight: 32608.17 Da        Isoelectric Point: 6.8844

>AT154365 WP_206001871.1 NZ_CP051515:55978-56862 [Paraburkholderia aromaticivorans]
MTPDTISAERDADEDRNGTTGDTAYRVPGLERGLKILTEFSPREPVLGAPELSRRLKIPRTTVFRLLQTLESLGFLERAD
KDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRNETGLTSHIVIRDGRDVVFVAKAQSHAPIFSSVKVNVGTRLPAY
ATTHGQVLMGDLTLDELKKLYPEPELERFTKQTPVTVDDLYERICDDARRGFAISESSFERGISVVSVPVRNDTGRIVAV
ITTTIPRHEIDASLLDSGLIDKVRRAADELSQRLNYRPKAGAKSGSNYMKALGL

Download         Length: 885 bp

>AT154365 NZ_CP068033:3933001-3933375 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References