Detailed information of TA system TA154364

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-RelB
• Location: 2355682..2356205
• Replicon: chromosome
• Accession: NZ_CP051514
• Organism: Paraburkholderia aromaticivorans strain AR20-38

Toxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HF916_RS11055
• Protein ID: WP_206001821.1
• Coordinates: 2355951..2356205 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: HF916_RS11050
• Protein ID: WP_168788829.1
• Coordinates: 2355682..2355942 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF916_RS11035	2351084..2351680	-	597	WP_168788826.1	DUF1173 family protein	-
HF916_RS11040	2351661..2352047	-	387	WP_168788827.1	DUF1173 family protein	-
HF916_RS11045	2352670..2355192	+	2523	WP_168788828.1	adenosylcobalamin-dependent ribonucleoside-diphosphate reductase	-
HF916_RS11050	2355682..2355942	+	261	WP_168788829.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HF916_RS11055	2355951..2356205	+	255	WP_206001821.1	Txe/YoeB family addiction module toxin	Toxin
HF916_RS11060	2356265..2356537	+	273	WP_168788831.1	hypothetical protein	-
HF916_RS11065	2356587..2356853	+	267	WP_168788832.1	hypothetical protein	-
HF916_RS11070	2356946..2357098	+	153	WP_168788833.1	hypothetical protein	-
HF916_RS11075	2357312..2357884	+	573	WP_168788834.1	hypothetical protein	-
HF916_RS11080	2357943..2358257	-	315	WP_168788835.1	hypothetical protein	-
HF916_RS11085	2358325..2358912	+	588	WP_168788836.1	hypothetical protein	-
HF916_RS11090	2358983..2359237	+	255	WP_168788837.1	hypothetical protein	-
HF916_RS11095	2359596..2359895	+	300	WP_168788838.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9983.34 Da
• Isoelectric Point: 8.8663

>T154364 WP_206001821.1 NZ_CP051514:2355951-2356205 [Paraburkholderia aromaticivorans]
MNILWTAEAWDDYVYWQGPDKKTLKRINQLVKDMQRSPFDGVGKPESLKQNLTGFWSRRIDETNRLVYEVAGTQINIVSC
RYHY

Nucleotide

• Length: 255 bp

>T154364 NZ_CP068033:1867613-1867715 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9676.07 Da
• Isoelectric Point: 7.3198

>AT154364 WP_168788829.1 NZ_CP051514:2355682-2355942 [Paraburkholderia aromaticivorans]
MRTIPFSDARANLKRVIDQVVDDVDVTLITRRDAPNAILMSQEHYDSLMETVHLLRSPANVAHLERSIAQARAGKVKPRK
LAEDAE

Nucleotide

• Length: 261 bp

>AT154364 NZ_CP068033:c1867722-1867577 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT