Detailed information of TA system TA154363

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 2140553..2141439
• Replicon: chromosome
• Accession: NZ_CP051514
• Organism: Paraburkholderia aromaticivorans strain AR20-38

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: -
• Locus tag: HF916_RS10020
• Protein ID: WP_168788706.1
• Coordinates: 2140921..2141439 (+)
• Length: 173 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: -
• Locus tag: HF916_RS10015
• Protein ID: WP_168788705.1
• Coordinates: 2140553..2140924 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF916_RS10000	2135739..2136413	+	675	WP_168788702.1	response regulator	-
HF916_RS10005	2136608..2137735	+	1128	WP_168788703.1	porin	-
HF916_RS10010	2137847..2139586	+	1740	WP_168788704.1	Tar ligand binding domain-containing protein	-
HF916_RS10015	2140553..2140924	+	372	WP_168788705.1	DNA-binding protein	Antitoxin
HF916_RS10020	2140921..2141439	+	519	WP_168788706.1	RES family NAD+ phosphorylase	Toxin
HF916_RS10025	2142225..2142476	-	252	WP_168788093.1	hypothetical protein	-
HF916_RS10030	2142573..2144210	-	1638	WP_168788092.1	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	-
HF916_RS10035	2144304..2145269	-	966	WP_168789021.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (12-155)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 173 a.a.
• Molecular weight: 19707.99 Da
• Isoelectric Point: 5.0206

>T154363 WP_168788706.1 NZ_CP051514:2140921-2141439 [Paraburkholderia aromaticivorans]
MILTDLPKGTMLYRAHAPRWADRPTSGAGAALKGGRFNREGVEALYLSVEELTALREYQQTSPFLPPCTMCSYSAELRDL
VDLRQLDRSSWDELWHDWREDWRYWKFDQHIEPPTWVLGDLVRESGYPGIVFQSQTHDGGTNVVVFSDRLHGDNSIKVND
PGGQLPKDQSSW

Nucleotide

• Length: 519 bp

>T154363 NZ_CP068033:836456-836866 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13380.25 Da
• Isoelectric Point: 6.7259

>AT154363 WP_168788705.1 NZ_CP051514:2140553-2140924 [Paraburkholderia aromaticivorans]
MTVENFSGVLESAREAGTSRLSAVNLANVLGLQQQDLATLAGVHRNTLRTHPESPRLQAALRDLMRVVSAAVAVQPDIER
ALFFIKNSPIPAFRHKTILQLVQDGRTEDAIDYLESISAGFVG

Nucleotide

• Length: 372 bp

>AT154363 NZ_CP068033:836209-836475 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTTGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA