Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1269804..1270399 Replicon chromosome
Accession NZ_CP051514
Organism Paraburkholderia aromaticivorans strain AR20-38

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HF916_RS05935 Protein ID WP_168788146.1
Coordinates 1269804..1270094 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HF916_RS05940 Protein ID WP_168788147.1
Coordinates 1270091..1270399 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF916_RS05915 1265191..1265775 + 585 WP_168788143.1 hemerythrin domain-containing protein -
HF916_RS05920 1266199..1266555 + 357 WP_168788144.1 STAS/SEC14 domain-containing protein -
HF916_RS05925 1267298..1267573 + 276 WP_168788145.1 PIN/TRAM domain-containing protein -
HF916_RS05930 1267834..1268620 + 787 Protein_1177 IS30 family transposase -
HF916_RS05935 1269804..1270094 - 291 WP_168788146.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HF916_RS05940 1270091..1270399 - 309 WP_168788147.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HF916_RS05945 1270678..1271408 + 731 Protein_1180 IS6 family transposase -
HF916_RS05950 1271897..1272301 - 405 WP_168789029.1 DUF1488 family protein -
HF916_RS05955 1272670..1273074 + 405 WP_168788148.1 hypothetical protein -
HF916_RS05960 1273542..1273937 + 396 WP_168788149.1 hypothetical protein -
HF916_RS05965 1274072..1274401 - 330 WP_168788150.1 chaperone modulator CbpM -
HF916_RS05970 1274398..1275339 - 942 WP_168788151.1 DnaJ domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1268087..1268620 533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-50)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11113.66 Da        Isoelectric Point: 4.8232

>T154361 WP_168788146.1 NZ_CP051514:c1270094-1269804 [Paraburkholderia aromaticivorans]
VRLEWSAFAIEDRNAIFDYIEDDSPYAAVVVDDRIRVQVRQLLQFPETGRPGRINGTRELVISRTPYIAAYQIKGETVRI
LRVLHGAQLWPDEMLD

Download         Length: 291 bp

>T154361 NZ_CP068033:332568-332936 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10972.38 Da        Isoelectric Point: 5.6328

>AT154361 WP_168788147.1 NZ_CP051514:c1270399-1270091 [Paraburkholderia aromaticivorans]
MAATALVQTRIDPALKERAAAVLDNMGLTVSDAVRILLTRVANEGALPFAFATDPAVHDAWFRAKVQEALDDPRPATPDE
EVEAHFARRRAAARHKAGEGDA

Download         Length: 309 bp

>AT154361 NZ_CP068033:332350-332571 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References