Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 296753..297330 Replicon chromosome
Accession NZ_CP051514
Organism Paraburkholderia aromaticivorans strain AR20-38

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HF916_RS01365 Protein ID WP_168787536.1
Coordinates 296965..297330 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HF916_RS01360 Protein ID WP_168787535.1
Coordinates 296753..296971 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF916_RS01320 292021..292233 - 213 Protein_259 carbohydrate ABC transporter permease -
HF916_RS01325 292393..292743 - 351 WP_168787530.1 hypothetical protein -
HF916_RS01330 293447..293911 - 465 WP_168787531.1 acyl-CoA thioesterase -
HF916_RS01335 294416..294715 - 300 WP_168787532.1 hypothetical protein -
HF916_RS01340 294728..295810 - 1083 WP_168787533.1 IS630 family transposase -
HF916_RS01345 295880..296175 + 296 Protein_264 transposase -
HF916_RS01350 296316..296561 + 246 WP_168787312.1 hypothetical protein -
HF916_RS01355 296504..296641 + 138 WP_168787534.1 hypothetical protein -
HF916_RS01360 296753..296971 + 219 WP_168787535.1 ribbon-helix-helix protein, CopG family Antitoxin
HF916_RS01365 296965..297330 + 366 WP_168787536.1 type II toxin-antitoxin system VapC family toxin Toxin
HF916_RS49730 297685..298089 + 405 WP_206001756.1 hypothetical protein -
HF916_RS01370 298119..298777 - 659 Protein_270 NAD-dependent formate dehydrogenase -
HF916_RS01375 299069..300202 + 1134 WP_168787537.1 aminomethyltransferase family protein -
HF916_RS01380 300267..300797 + 531 WP_168788944.1 glycine cleavage system protein R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 294728..295828 1100


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-101)

Antitoxin

Ribbon-helix-helix protein, CopG

(4-40)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13426.52 Da        Isoelectric Point: 6.3419

>T154360 WP_168787536.1 NZ_CP051514:296965-297330 [Paraburkholderia aromaticivorans]
MVRALFDTNILVDYLGGVSAAKKELSRYEYRAISTITWMEVLVGTTAEDEATIRAWMGSFEVVALDTAIANRAVEIRKQR
RIRLADAIVWASAQVNSLLLVSPNTKDFPADEPGVRVPCKI

Download         Length: 366 bp

>T154360 NZ_CP068031:1875891-1876079 [Staphylococcus saccharolyticus]
ATGAGTTTACATTTTTATATTCTATTATGGCTTGCCATACTGTTTATTATTGCAGGAACTATCTTATTAATTACAATGCT
AAATACTAAAAAAGAAGAAAGAAAAGAATCCTACTTAGGCTTTACAGTCATCTTCTTAATCTTTGGTATTACCATACTTA
TCTACACGATTATATTTGGAATTTTGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8262.40 Da        Isoelectric Point: 5.1053

>AT154360 WP_168787535.1 NZ_CP051514:296753-296971 [Paraburkholderia aromaticivorans]
MSRILVDLPDAQVEELAVLAEAERRPRAAVIRDAIEAYIANHKQARGADVFGLWKNKKIDGLEYQQELRSEW

Download         Length: 219 bp

>AT154360 NZ_CP068031:1875602-1875859 [Staphylococcus saccharolyticus]
ATGAAACTAATTATAATAAATGTAATTAACGTGATATTAACTATACTATTTATGGCTTTTAACGTACTCATTACCTACAA
CGAGAATATTAATAACAATTTGTGGTTAGTACCAGGATTAATCATTTTTGGTATTACTTTACTTACAAGTTTAACAATAG
CTATTGTGTATACTGATTTATTTAGTGAAATTTTATTTTTTATCAATATCGTTTTAGCACTATATTATATCTATCCTATT
ATTTATGAGTTCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References