Detailed information of TA system TA154346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1510500..1511685
• Replicon: chromosome
• Accession: NZ_CP051504
• Organism: Helicobacter pylori strain SHIM-011

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HG563_RS07230
• Protein ID: WP_202273406.1
• Coordinates: 1510500..1511258 (-)
• Length: 253 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: HG563_RS07235
• Protein ID: WP_000248393.1
• Coordinates: 1511248..1511685 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG563_RS07220	1507833..1508993	+	1161	WP_202273404.1	L-seryl-tRNA(Sec) selenium transferase	-
HG563_RS07225	1509081..1510268	+	1188	WP_202273405.1	transcription termination/antitermination protein NusA	-
HG563_RS07230	1510500..1511258	-	759	WP_202273406.1	hypothetical protein	Toxin
HG563_RS07235	1511248..1511685	-	438	WP_000248393.1	SocA family protein	Antitoxin
HG563_RS07240	1511894..1513519	-	1626	WP_041199660.1	RNA-directed DNA polymerase	-
HG563_RS07245	1513530..1514054	-	525	WP_000413001.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 253 a.a.
• Molecular weight: 29647.68 Da
• Isoelectric Point: 7.2430

>T154346 WP_202273406.1 NZ_CP051504:c1511258-1510500 [Helicobacter pylori]
METKEENKDKKLEEIIVLLCEEGDLSSQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMMLTQNIKALKEIQ
NNREVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEEKDKQENFKKPIFWFNLMVTILFMIDFFGE
LHIIQRLVSKYL

Nucleotide

• Length: 759 bp

>T154346 NZ_CP068018:4989169-4989480 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17280.38 Da
• Isoelectric Point: 6.3468

>AT154346 WP_000248393.1 NZ_CP051504:c1511685-1511248 [Helicobacter pylori]
MVNTLELAKYILKHSNKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINHSIKKCNEKSYWDLVKESHKEDGAWHKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT154346 NZ_CP068018:4989481-4989771 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA