Detailed information of TA system TA154335

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/DUF4065(antitoxin)
• Location: 1547775..1548945
• Replicon: chromosome
• Accession: NZ_CP051498
• Organism: Helicobacter pylori strain PUNO-006

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: HG569_RS07390
• Protein ID: WP_202272609.1
• Coordinates: 1547775..1548518 (-)
• Length: 248 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: HG569_RS07395
• Protein ID: WP_202272611.1
• Coordinates: 1548508..1548945 (-)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HG569_RS07380	1545094..1546253	+	1160	Protein_1430	L-seryl-tRNA(Sec) selenium transferase	-
HG569_RS07385	1546341..1547528	+	1188	WP_202272607.1	transcription termination/antitermination protein NusA	-
HG569_RS07390	1547775..1548518	-	744	WP_202272609.1	hypothetical protein	Toxin
HG569_RS07395	1548508..1548945	-	438	WP_202272611.1	SocA family protein	Antitoxin
HG569_RS07400	1549171..1550799	-	1629	WP_097683120.1	RNA-directed DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Antitoxin SocA-like, Panacea domain (24-119)

Sequences

Toxin

Protein

• Length: 248 a.a.
• Molecular weight: 28964.88 Da
• Isoelectric Point: 7.2426

>T154335 WP_202272609.1 NZ_CP051498:c1548518-1547775 [Helicobacter pylori]
METKEEDKDKKLEEIIVLLCKEGDLSGQKDQIIKDLKEIYEGEYKHKYSKITTIILNSTRDKEQAFMTLTQNIKTLKEIQ
DIKEVESIKPKLEKLYDHMNLECIRLQDFDEKMSRVKDVSIKLDDLNKNYKKLSEELNKQQTQYITILGIFASIVLTFVG
GLAFSTSVLSNIDKANAYRLVFVMAFIALFFGNILYLLFSFLSKISLSKEEKDKQENFKKPIFWFNLMVTILFMIGFFGE
LHIKYKD

Nucleotide

• Length: 744 bp

>T154335 NZ_CP068018:c994937-994662 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 17273.40 Da
• Isoelectric Point: 5.3941

>AT154335 WP_202272611.1 NZ_CP051498:c1548945-1548508 [Helicobacter pylori]
MVNTLELAKYILKHSDKELSNLELQKTLYFTELDYIKKFDKHLVSDDFEAWKYGPVAREVYYEYRNYGANSIDKPKEETL
SQNLREDELETINCSIKKCNEKSYWDLVKESHKEDGAWYKSFKEDRKEIISKDLIKQEAKQANGN

Nucleotide

• Length: 438 bp

>AT154335 NZ_CP068018:994672-995094 [Salmonella enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT