Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1211035..1211551 Replicon chromosome
Accession NZ_CP051490
Organism Klebsiella pneumoniae strain M297-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HGK25_RS05860 Protein ID WP_040216106.1
Coordinates 1211267..1211551 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HGK25_RS05855 Protein ID WP_002886901.1
Coordinates 1211035..1211277 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGK25_RS05840 (HGK25_05960) 1207063..1207803 + 741 WP_004186692.1 KDGP aldolase family protein -
HGK25_RS05845 (HGK25_05965) 1207870..1209024 + 1155 WP_040216103.1 lactonase family protein -
HGK25_RS05850 (HGK25_05970) 1209047..1210957 + 1911 WP_040216105.1 PRD domain-containing protein -
HGK25_RS05855 (HGK25_05975) 1211035..1211277 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HGK25_RS05860 (HGK25_05980) 1211267..1211551 + 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HGK25_RS05865 (HGK25_05985) 1211555..1212019 - 465 WP_032418146.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HGK25_RS05870 (HGK25_05990) 1212327..1214465 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HGK25_RS05875 (HGK25_05995) 1214822..1215565 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HGK25_RS05880 (HGK25_06000) 1215568..1215741 - 174 WP_032425422.1 hypothetical protein -
HGK25_RS05885 (HGK25_06005) 1215826..1216134 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T154310 WP_040216106.1 NZ_CP051490:1211267-1211551 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T154310 NZ_CP067994:2616775-2616882 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT154310 WP_002886901.1 NZ_CP051490:1211035-1211277 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT154310 NZ_CP067994:c2616725-2616662 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References