Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 38215..38852 Replicon plasmid pwem22
Accession NZ_CP051489
Organism Kosakonia sp. SMBL-WEM22

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HF650_RS24460 Protein ID WP_187802914.1
Coordinates 38670..38852 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HF650_RS24455 Protein ID WP_187802913.1
Coordinates 38215..38622 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HF650_RS24425 34140..34502 + 363 WP_187802910.1 hypothetical protein -
HF650_RS24430 34617..34880 - 264 WP_187802940.1 hypothetical protein -
HF650_RS24435 34908..35735 - 828 WP_187802911.1 ParA family protein -
HF650_RS24440 35989..36412 + 424 Protein_31 DUF4158 domain-containing protein -
HF650_RS24445 36498..37304 - 807 WP_187802912.1 DUF4263 domain-containing protein -
HF650_RS24450 37611..37897 + 287 Protein_33 transposase -
HF650_RS24455 38215..38622 - 408 WP_187802913.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HF650_RS24460 38670..38852 - 183 WP_187802914.1 type II toxin-antitoxin system HicA family toxin Toxin
HF650_RS24465 39566..40153 - 588 Protein_36 recombinase family protein -
HF650_RS24470 40644..41075 - 432 WP_187802915.1 hypothetical protein -
HF650_RS24475 41523..42302 + 780 WP_187802916.1 conjugal transfer protein TraX -
HF650_RS24480 42380..42568 + 189 WP_187802917.1 hypothetical protein -
HF650_RS24485 42666..42983 + 318 WP_187802918.1 hypothetical protein -
HF650_RS24490 42973..43776 - 804 WP_187802919.1 DUF4225 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..157340 157340


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6663.79 Da        Isoelectric Point: 10.4971

>T154306 WP_187802914.1 NZ_CP051489:c38852-38670 [Kosakonia sp. SMBL-WEM22]
MSSGELIKKLTQAGWVHVRTKGSHHIFEKDGELNPKVVPHPTKDLAVGTLHKILKQLGEK

Download         Length: 183 bp

>T154306 NZ_CP067994:2295086-2296408 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14904.47 Da        Isoelectric Point: 4.4142

>AT154306 WP_187802913.1 NZ_CP051489:c38622-38215 [Kosakonia sp. SMBL-WEM22]
MKYPVYLHQAESGTFSGFVPDIAGCYFAGDNIDEAIADAHAAIDAYLEYQSEKGREVPDAGTINDYKDDEDCRGGIWGLV
DIDTSKYQGKAVKLNITLPQNLLSRIDTYVSSNGDYTSRSGFLAELARRELLKHS

Download         Length: 408 bp

>AT154306 NZ_CP067994:2294820-2295086 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References