Detailed information of TA system TA154292

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1253156..1253772
• Replicon: chromosome
• Accession: NZ_CP051488
• Organism: Kosakonia sp. SMBL-WEM22

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: A0A807LE76
• Locus tag: HF650_RS05925
• Protein ID: WP_023478287.1
• Coordinates: 1253156..1253374 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: HF650_RS05930
• Protein ID: WP_187801579.1
• Coordinates: 1253398..1253772 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HF650_RS05895	1249094..1250464	+	1371	WP_187801574.1	PTS transporter subunit EIIC	-
HF650_RS05900	1250677..1250937	+	261	WP_187801575.1	type B 50S ribosomal protein L31	-
HF650_RS05905	1250941..1251081	+	141	WP_023478279.1	type B 50S ribosomal protein L36	-
HF650_RS05910	1251078..1251779	-	702	WP_187801576.1	GNAT family N-acetyltransferase	-
HF650_RS05915	1251907..1252410	-	504	WP_187801577.1	YlaC family protein	-
HF650_RS05920	1252511..1253080	-	570	WP_187801578.1	maltose O-acetyltransferase	-
HF650_RS05925	1253156..1253374	-	219	WP_023478287.1	hemolysin expression modulator Hha	Toxin
HF650_RS05930	1253398..1253772	-	375	WP_187801579.1	Hha toxicity modulator TomB	Antitoxin
HF650_RS05935	1254303..1257452	-	3150	WP_187801580.1	multidrug efflux RND transporter permease subunit AcrB	-
HF650_RS05940	1257475..1258674	-	1200	WP_187801581.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8657.04 Da
• Isoelectric Point: 7.9892

>T154292 WP_023478287.1 NZ_CP051488:c1253374-1253156 [Kosakonia sp. SMBL-WEM22]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELTDDELTVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Nucleotide

• Length: 219 bp

>T154292 NZ_CP067993:259700-260002 [Stenotrophomonas maltophilia]
ATGGCCATCAAGAGAAAAGTCGAACTCAAATCATTTGATGTGGCCGAGCATCTTCGGACGCCGGAGGAGATGGCGGCTTA
TCTCGACGCCTGCATCGAAGAAAGCGACGGTGATTCTGCATTTATCGCCAAGGCGCTCGGCGATATCGCTCGCGCTCAGG
GCATGAGCAAGGTTGCGCGTGCGGCGGGCTTGTCGCGTGAGAGTCTGTATCGCGCACTGTCGGGCGAGCGCAGTCCGGAT
TTCGCGACCATCCTGAAGGTGACCCGGGCCCTGGGTGTGCGATTGCACGCCAGCGCTGTGTAA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14473.33 Da
• Isoelectric Point: 6.3982

>AT154292 WP_187801579.1 NZ_CP051488:c1253772-1253398 [Kosakonia sp. SMBL-WEM22]
MDEYSPKRHDIAQLKFLCETLHHDCLTNLKESHHGWVNDPTSAINLQLNELIEHIATFALNYKIKHDEDNKLIELIDEYL
DDTFMLFSSYGINTHDLQKWRKTGSKLFRSFVNVSKANPVSHSC

Nucleotide

• Length: 375 bp

>AT154292 NZ_CP067993:259354-259641 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCCGGAGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCGGGTTACCGCGTGTACTACACCCAGCGCGGCAGGCAGTTGGTGATTCTCCTGGTTGGAGGCGACAAGGGTTCA
CAGCAGCGCGATATCGAGAAGGCCAGGGAGATTGCGCGTGCCCTGTGA

Structures

Toxin

• AlphaFold DB: A0A807LE76