Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1856805..1857421 Replicon chromosome
Accession NZ_CP051487
Organism Pseudomonas umsongensis strain CY-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A1H1STD3
Locus tag HGP31_RS08460 Protein ID WP_033044075.1
Coordinates 1856805..1857017 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID S2F0D0
Locus tag HGP31_RS08465 Protein ID WP_020796998.1
Coordinates 1857017..1857421 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGP31_RS08435 1853444..1853980 + 537 WP_020796992.1 DsbE family thiol:disulfide interchange protein -
HGP31_RS08440 1853977..1854447 + 471 WP_020796993.1 cytochrome c-type biogenesis protein CcmH -
HGP31_RS08445 1854444..1855646 + 1203 WP_083348448.1 c-type cytochrome biogenesis protein CcmI -
HGP31_RS08450 1855659..1856066 + 408 WP_168757459.1 hypothetical protein -
HGP31_RS08455 1856094..1856660 + 567 WP_168757460.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
HGP31_RS08460 1856805..1857017 + 213 WP_033044075.1 type II toxin-antitoxin system HicA family toxin Toxin
HGP31_RS08465 1857017..1857421 + 405 WP_020796998.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HGP31_RS08470 1857480..1858685 - 1206 WP_033044076.1 MFS transporter -
HGP31_RS08475 1858910..1859353 + 444 WP_020797000.1 hypothetical protein -
HGP31_RS08480 1859473..1860468 - 996 WP_168757461.1 sulfate ABC transporter substrate-binding protein -
HGP31_RS08485 1860657..1861481 - 825 WP_020797002.1 ion transporter -
HGP31_RS08490 1861503..1862417 - 915 WP_168757462.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7894.16 Da        Isoelectric Point: 10.1896

>T154289 WP_033044075.1 NZ_CP051487:1856805-1857017 [Pseudomonas umsongensis]
VQSRLLIKELMEAGWTLDRVTGSHHIFTHRYNPYTIPIPHPKKDLPVGAVKSIRRRAGLYCPPASYAGDP

Download         Length: 213 bp

>T154289 NZ_CP067992:c1626424-1626170 [Streptococcus mitis]
ATGCTACTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAACTCAAGACAAGAAAACACTCAAAAGAAT
CAACAAGATAATCAAGGATATTCAACGTAATCCGTTTACAGGAATAGGAAAACCAGAACCACTCAAGTATGACTACCAAG
GAGCTTGGTCACGTCGTATTGATGCAGAAAATCGATTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCTTTC
AAAGATCATTACTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14782.72 Da        Isoelectric Point: 4.3062

>AT154289 WP_020796998.1 NZ_CP051487:1857017-1857421 [Pseudomonas umsongensis]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQELAADGESIPMPTSASVHRSNPEFADMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRN

Download         Length: 405 bp

>AT154289 NZ_CP067992:c1626682-1626428 [Streptococcus mitis]
ATGGAAGCAGTTCTTTACTCAACATTCCGAAATCATTTAAAAGATTACATGAAGAAGGTAAATGATGAATTTGAACCTTT
AACGGTGGTCAATAAAAATCCAGACGAGGACATTGTAGTCCTTTCAAAGAGCGAGTGGGATAGCATTCAGGAAACTTTGA
GAATTGCTCAAAACAAGGAGTTATCAGACAAGGTCTTGCGAGGAATGGCTCAAGTCCGTGCTGGAAGCACTCAGATCCAT
GTTATTGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H1STD3

Antitoxin

Source ID Structure
AlphaFold DB S2F0D0

References