Detailed information of TA system TA154287

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1174056..1174561
• Replicon: chromosome
• Accession: NZ_CP051487
• Organism: Pseudomonas umsongensis strain CY-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: S2F4C5
• Locus tag: HGP31_RS05165
• Protein ID: WP_020795568.1
• Coordinates: 1174056..1174310 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HGP31_RS05170
• Protein ID: WP_020795569.1
• Coordinates: 1174307..1174561 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGP31_RS05140	1169549..1170067	+	519	WP_020795563.1	peptide-methionine (R)-S-oxide reductase MsrB	-
HGP31_RS05145	1170088..1170795	+	708	WP_033043128.1	peptide-methionine (S)-S-oxide reductase MsrA	-
HGP31_RS05150	1170802..1171815	-	1014	WP_151140524.1	sensor domain-containing diguanylate cyclase	-
HGP31_RS05155	1171893..1172798	-	906	WP_020795566.1	LysR family transcriptional regulator	-
HGP31_RS05160	1172901..1174088	+	1188	WP_151140526.1	aspartate aminotransferase family protein	-
HGP31_RS05165	1174056..1174310	-	255	WP_020795568.1	Txe/YoeB family addiction module toxin	Toxin
HGP31_RS05170	1174307..1174561	-	255	WP_020795569.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HGP31_RS05175	1174743..1175237	-	495	WP_083348259.1	AAA family ATPase	-
HGP31_RS05180	1175379..1177298	-	1920	WP_168757270.1	alkaline phosphatase family protein	-
HGP31_RS05185	1177426..1177767	+	342	WP_168757271.1	potassium channel family protein	-
HGP31_RS05190	1177829..1178197	+	369	WP_020795573.1	PH domain-containing protein	-
HGP31_RS05195	1178386..1178838	+	453	WP_020795574.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10011.54 Da
• Isoelectric Point: 6.7086

>T154287 WP_020795568.1 NZ_CP051487:c1174310-1174056 [Pseudomonas umsongensis]
MNIEFTPEGWDDYLWFQQNDKAGLKRINLLIKAILREPFEGLGKPEPLKHNLSGFWSRRITAEHRLVYTIEDGELCVVMC
RYHY

Nucleotide

• Length: 255 bp

>T154287 NZ_CP067992:545266-545616 [Streptococcus mitis]
ATGGATTATAAAAAATATAGGATTTTGTATTCTCCTAGAGTGATTGATAGTCTGGATAAAATATATCAGTATATAGCGGA
GGAAATTGGTTCTGTAGAGGCTGCGAGACGAAAAGTAGCCAATATTAGAAAAGATATTAATCGTCTAGAAATTTTCCCCC
AAGCTGGATTTGATGCCGATGAAAAATTTGGTAAGAAATTAGATCCTCACTATCAAACGCGAGGATTGACCTTGAGTAAG
GATTACATCGTATTATATACAATTGTGGAGGATACTGTCAGACTTGCTTATTTACTCCCTTCAAAAAGTGATTATATGAA
ATTATTTAAGACTAAGTCAAGATACGACTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9527.92 Da
• Isoelectric Point: 8.5374

>AT154287 WP_020795569.1 NZ_CP051487:c1174561-1174307 [Pseudomonas umsongensis]
MHTINYTTARAHLAETMDRVNEDRTPLLVTRQKGEPVVMMSLAEYNALEETAYLLRSPANAERLIKSIGNLRAGKTKSRQ
LIEE

Nucleotide

• Length: 255 bp

>AT154287 NZ_CP067992:544989-545276 [Streptococcus mitis]
ATGGCTATAGCGAATTCAAGTAAAGTTGTGACCTTCCAAGCTAATAGAGAATTAGTAAATGATGCCATGGAAGTGTTAAA
AGAAAAAAATCTCTCTCTTTCTTCAGCACTAAGATTATTTTTAAAGAATGTTGCCGTAACAAATGAAGTAGATTTACTGA
GTGAAGAGGAATTGGAGAAGGAGTATTTATTTAGGCAATTACAAGCAGAAGTTCAAGAAAGTTATGCTAAGATTGAGGCT
GGAAATTACTTGACAGATGAGGATATCGTGACACGCTATGGATTATAA

Structures

Toxin

• AlphaFold DB: S2F4C5