Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1165631..1166156 Replicon chromosome
Accession NZ_CP051486
Organism Streptomyces pratensis strain S10

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag HED23_RS05245 Protein ID WP_203182254.1
Coordinates 1165631..1165894 (-) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag HED23_RS05250 Protein ID WP_203182255.1
Coordinates 1165887..1166156 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HED23_RS05225 1161740..1162726 + 987 WP_203182250.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
HED23_RS05230 1162833..1163570 + 738 WP_203182251.1 ROK family protein -
HED23_RS05235 1163574..1164179 - 606 WP_203182252.1 hypothetical protein -
HED23_RS05240 1164409..1165497 + 1089 WP_203182253.1 redox-regulated ATPase YchF -
HED23_RS05245 1165631..1165894 - 264 WP_203182254.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HED23_RS05250 1165887..1166156 - 270 WP_203182255.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HED23_RS05255 1166442..1166663 - 222 WP_203182256.1 hypothetical protein -
HED23_RS05260 1166650..1167135 + 486 WP_203182257.1 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
HED23_RS05265 1167371..1167925 + 555 WP_203182258.1 NUDIX domain-containing protein -
HED23_RS05270 1167992..1168807 - 816 WP_203182259.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10098.46 Da        Isoelectric Point: 7.2017

>T154286 WP_203182254.1 NZ_CP051486:c1165894-1165631 [Streptomyces pratensis]
VSEYRTVFRPEAQDELRKIPRETALRILAKLTELESDPLGFNTTALVSQPDRRRLRVGDYRIVYTIDNGELVVWVVHVGH
RSTVYDT

Download         Length: 264 bp

>T154286 NZ_CP067966:c4831345-4831061 [Klebsiella quasipneumoniae]
ATGACCTATGAACTGGCGTTTGATCCGCGTGCCTGGCGCGAATGGCAGAAGCTTGGCGAGACGATCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGGTTGTGGAGAATCCGCGAATTGCATCGGCCAGTCTGAGTGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGGGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10303.76 Da        Isoelectric Point: 4.6265

>AT154286 WP_203182255.1 NZ_CP051486:c1166156-1165887 [Streptomyces pratensis]
MTQPLPIETIRDVRAHLAEVVERADRDDVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARSE

Download         Length: 270 bp

>AT154286 NZ_CP067966:c4831577-4831335 [Klebsiella quasipneumoniae]
ATGGCCACGCTCAACGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACGCC
AACGGAGGCGGTGCGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCAGTGAAAAGTATGACTATCAGCGATA
GCGAAGCGGCATTATTACGCACCGTCCGCGAGCGGCTGGAAAACCCGCAGCCGGAGGTGAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References