Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1272121..1272894 Replicon chromosome
Accession NZ_CP051484
Organism Staphylococcus aureus strain NGA71

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag HGO96_RS06175 Protein ID WP_054189550.1
Coordinates 1272121..1272270 (-) Length 50 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag HGO96_RS06180 Protein ID WP_001251219.1
Coordinates 1272295..1272894 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO96_RS06160 (1268192) 1268192..1269013 + 822 WP_054189552.1 RluA family pseudouridine synthase -
HGO96_RS06165 (1269480) 1269480..1270865 - 1386 WP_054189551.1 class II fumarate hydratase -
HGO96_RS06170 (1271061) 1271061..1271456 - 396 WP_000901023.1 hypothetical protein -
HGO96_RS06175 (1272121) 1272121..1272270 - 150 WP_054189550.1 SAS053 family protein Toxin
HGO96_RS06180 (1272295) 1272295..1272894 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
HGO96_RS06185 (1273053) 1273053..1273523 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
HGO96_RS06190 (1273528) 1273528..1274655 - 1128 WP_054189549.1 tRNA epoxyqueuosine(34) reductase QueG -
HGO96_RS06195 (1274806) 1274806..1275528 - 723 WP_054189583.1 amino acid ABC transporter ATP-binding protein -
HGO96_RS06200 (1275521) 1275521..1276978 - 1458 WP_054189548.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 50 a.a.        Molecular weight: 5862.20 Da        Isoelectric Point: 3.9075

>T154279 WP_054189550.1 NZ_CP051484:c1272270-1272121 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVNDFEDLKELGKEMEQISDQNEQEKNSEEDN

Download         Length: 150 bp

>T154279 NZ_CP067431:84276-84425 [Escherichia coli O22:H8]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT154279 WP_001251219.1 NZ_CP051484:c1272894-1272295 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT154279 NZ_CP067431:c84227-84171 [Escherichia coli O22:H8]
GTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References