Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 888603..889391 | Replicon | chromosome |
| Accession | NZ_CP051484 | ||
| Organism | Staphylococcus aureus strain NGA71 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | HGO96_RS04290 | Protein ID | WP_000525004.1 |
| Coordinates | 888930..889391 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | HGO96_RS04285 | Protein ID | WP_000333630.1 |
| Coordinates | 888603..888917 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HGO96_RS04225 (883745) | 883745..884911 | - | 1167 | WP_000762547.1 | DUF2800 domain-containing protein | - |
| HGO96_RS04230 (884908) | 884908..885270 | - | 363 | WP_000985984.1 | hypothetical protein | - |
| HGO96_RS04235 (885285) | 885285..885608 | - | 324 | WP_000175001.1 | hypothetical protein | - |
| HGO96_RS04240 (885687) | 885687..885848 | - | 162 | WP_001285954.1 | DUF1270 domain-containing protein | - |
| HGO96_RS04245 (885861) | 885861..886124 | - | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| HGO96_RS04250 (886149) | 886149..886364 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| HGO96_RS04255 (886419) | 886419..886784 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| HGO96_RS04260 (886753) | 886753..886998 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| HGO96_RS04265 (887054) | 887054..887263 | + | 210 | WP_000642492.1 | hypothetical protein | - |
| HGO96_RS04270 (887253) | 887253..887396 | - | 144 | WP_000939498.1 | hypothetical protein | - |
| HGO96_RS04275 (887425) | 887425..888201 | - | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| HGO96_RS04280 (888215) | 888215..888451 | - | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| HGO96_RS04285 (888603) | 888603..888917 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| HGO96_RS04290 (888930) | 888930..889391 | + | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| HGO96_RS04295 (889409) | 889409..889843 | + | 435 | WP_000755718.1 | hypothetical protein | - |
| HGO96_RS04300 (889872) | 889872..890267 | + | 396 | WP_000449655.1 | hypothetical protein | - |
| HGO96_RS04305 (890357) | 890357..890503 | + | 147 | WP_001795334.1 | hypothetical protein | - |
| HGO96_RS04310 (890500) | 890500..891114 | - | 615 | WP_000191466.1 | hypothetical protein | - |
| HGO96_RS04315 (891240) | 891240..892445 | + | 1206 | WP_000264751.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | lukF-PV / lukS-PV | 841227..910083 | 68856 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T154276 WP_000525004.1 NZ_CP051484:888930-889391 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T154276 NZ_CP067430:86950-87252 [Escherichia coli O22:H8]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTGTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTGTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT154276 WP_000333630.1 NZ_CP051484:888603-888917 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT154276 NZ_CP067430:87323-87661 [Escherichia coli O22:H8]
ATGAAACAGGCAACCAGAAAACCGACGACCGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTGAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGTAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGATCTGTGG
GAAGTCGAAAATGATATGCGCGTTCAGGAAGAGTTAAGTCGTATCAATACTGCTGAAAAATTTATTTCTCAGCGGAACCT
GAATAAAAAAGCAGCCTGA
ATGAAACAGGCAACCAGAAAACCGACGACCGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTGAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGTAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGATCTGTGG
GAAGTCGAAAATGATATGCGCGTTCAGGAAGAGTTAAGTCGTATCAATACTGCTGAAAAATTTATTTCTCAGCGGAACCT
GAATAAAAAAGCAGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I7Y5B3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7YIA0 |