Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 888603..889391 Replicon chromosome
Accession NZ_CP051484
Organism Staphylococcus aureus strain NGA71

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag HGO96_RS04290 Protein ID WP_000525004.1
Coordinates 888930..889391 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag HGO96_RS04285 Protein ID WP_000333630.1
Coordinates 888603..888917 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO96_RS04225 (883745) 883745..884911 - 1167 WP_000762547.1 DUF2800 domain-containing protein -
HGO96_RS04230 (884908) 884908..885270 - 363 WP_000985984.1 hypothetical protein -
HGO96_RS04235 (885285) 885285..885608 - 324 WP_000175001.1 hypothetical protein -
HGO96_RS04240 (885687) 885687..885848 - 162 WP_001285954.1 DUF1270 domain-containing protein -
HGO96_RS04245 (885861) 885861..886124 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
HGO96_RS04250 (886149) 886149..886364 - 216 WP_001097552.1 hypothetical protein -
HGO96_RS04255 (886419) 886419..886784 + 366 WP_001128433.1 hypothetical protein -
HGO96_RS04260 (886753) 886753..886998 - 246 WP_001025401.1 DUF2829 domain-containing protein -
HGO96_RS04265 (887054) 887054..887263 + 210 WP_000642492.1 hypothetical protein -
HGO96_RS04270 (887253) 887253..887396 - 144 WP_000939498.1 hypothetical protein -
HGO96_RS04275 (887425) 887425..888201 - 777 WP_001148544.1 Rha family transcriptional regulator -
HGO96_RS04280 (888215) 888215..888451 - 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
HGO96_RS04285 (888603) 888603..888917 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
HGO96_RS04290 (888930) 888930..889391 + 462 WP_000525004.1 hypothetical protein Toxin
HGO96_RS04295 (889409) 889409..889843 + 435 WP_000755718.1 hypothetical protein -
HGO96_RS04300 (889872) 889872..890267 + 396 WP_000449655.1 hypothetical protein -
HGO96_RS04305 (890357) 890357..890503 + 147 WP_001795334.1 hypothetical protein -
HGO96_RS04310 (890500) 890500..891114 - 615 WP_000191466.1 hypothetical protein -
HGO96_RS04315 (891240) 891240..892445 + 1206 WP_000264751.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukF-PV / lukS-PV 841227..910083 68856


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T154276 WP_000525004.1 NZ_CP051484:888930-889391 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T154276 NZ_CP067430:86950-87252 [Escherichia coli O22:H8]
ATGACCAAAAAAATTAACATAAAGGATTTCAGGGATGCGTGGCTTGATGATTTTTTTGAATTTTCAACACCACATAGAAA
GATACCTCCTGATATTCATATGACATTGTCACGGAAGTTGGACATTATCAATGCCGCAACTACCTGTAAGGATTTAAGAT
CACCACCAGGTAATCGGTATGAGGAACTGTCAGGGAAGCTAAATGGCTATTCATCAGTAAGGGTGAATAAGCAATATAGG
TTAATTTTTAAGTGGGTTAACGGAAAGGCCGAGGACTTGTATCTCGACCCTCACAAATACTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT154276 WP_000333630.1 NZ_CP051484:888603-888917 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT154276 NZ_CP067430:87323-87661 [Escherichia coli O22:H8]
ATGAAACAGGCAACCAGAAAACCGACGACCGTAGGTGATATCCTGCTGTACGAATACCTGGAGCCGTTAGAGCTGAAGAT
CAACGAGTTAGCAGAAATACTTCATGTTCATCGTAACACCGTAAGTGCTCTTGTTAATAATAATCGTAAGCTAACGATGG
ATATGGCATATCGCCTGGCAAAAGCATTCGATACTTCTGTAGATTTTTGGATTAATCTTCAGACCGCAGTAGATCTGTGG
GAAGTCGAAAATGATATGCGCGTTCAGGAAGAGTTAAGTCGTATCAATACTGCTGAAAAATTTATTTCTCAGCGGAACCT
GAATAAAAAAGCAGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References