Detailed information of TA system TA154272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 190663..191140
• Replicon: chromosome
• Accession: NZ_CP051484
• Organism: Staphylococcus aureus strain NGA71

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: HGO96_RS00950
• Protein ID: WP_000052076.1
• Coordinates: 190663..190851 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: HGO96_RS00955
• Protein ID: WP_001059689.1
• Coordinates: 190880..191140 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HGO96_RS00920 (186613)	186613..187170	+	558	WP_054189291.1	hypothetical protein	-
HGO96_RS00925 (187512)	187512..188198	+	687	WP_054189292.1	thermonuclease family protein	-
HGO96_RS00930 (188555)	188555..188755	+	201	WP_001059082.1	cold-shock protein	-
HGO96_RS00935 (189253)	189253..189471	-	219	WP_054189293.1	hypothetical protein	-
HGO96_RS00940 (189533)	189533..189817	-	285	WP_054189294.1	hypothetical protein	-
HGO96_RS00945 (189905)	189905..190474	-	570	WP_054189295.1	lipoprotein N-acylation protein LnsA	-
HGO96_RS00950 (190663)	190663..190851	-	189	WP_000052076.1	hypothetical protein	Toxin
HGO96_RS00955 (190880)	190880..191140	-	261	WP_001059689.1	hypothetical protein	Antitoxin
HGO96_RS00960 (191481)	191481..191684	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
HGO96_RS00965 (191681)	191681..191917	-	237	WP_000368687.1	hypothetical protein	-
HGO96_RS00970 (192141)	192141..192722	+	582	WP_054189296.1	histidine phosphatase family protein	-
HGO96_RS00975 (192795)	192795..193412	-	618	WP_054189297.1	LysE/ArgO family amino acid transporter	-
HGO96_RS00980 (193568)	193568..194062	-	495	WP_054189298.1	GNAT family N-acetyltransferase	-
HGO96_RS00985 (194461)	194461..194883	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
HGO96_RS00990 (195031)	195031..195747	+	717	WP_054189299.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T154272 WP_000052076.1 NZ_CP051484:c190851-190663 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T154272 NZ_CP067426:5080507-5080881 [Escherichia coli O22:H8]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10009.20 Da
• Isoelectric Point: 4.4986

>AT154272 WP_001059689.1 NZ_CP051484:c191140-190880 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYRFIG

Nucleotide

• Length: 261 bp

>AT154272 NZ_CP067426:5080049-5080417 [Escherichia coli O22:H8]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18