Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 2702277..2702791 Replicon chromosome
Accession NZ_CP051483
Organism Staphylococcus aureus strain NGA66a

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag HGO94_RS13365 Protein ID WP_000581793.1
Coordinates 2702582..2702791 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag HGO94_RS13360 Protein ID WP_000138932.1
Coordinates 2702277..2702570 (+) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO94_RS13340 (2697739) 2697739..2698380 + 642 WP_000483155.1 thiamine phosphate synthase -
HGO94_RS13345 (2698466) 2698466..2699338 + 873 WP_000725802.1 membrane protein insertase YidC -
HGO94_RS13350 (2699952) 2699952..2700599 - 648 WP_001187628.1 HD domain-containing protein -
HGO94_RS13355 (2700627) 2700627..2702111 - 1485 WP_000571549.1 cardiolipin synthase -
HGO94_RS13360 (2702277) 2702277..2702570 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
HGO94_RS13365 (2702582) 2702582..2702791 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
HGO94_RS13370 (2702919) 2702919..2703056 + 138 WP_000828354.1 Lmo0850 family protein -
HGO94_RS13375 (2703319) 2703319..2704521 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
HGO94_RS13380 (2704839) 2704839..2705909 + 1071 WP_000159627.1 D-alanine--D-alanine ligase -
HGO94_RS13385 (2705924) 2705924..2707282 + 1359 WP_054193129.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T154266 WP_000581793.1 NZ_CP051483:2702582-2702791 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T154266 NZ_CP067426:3165527-3165634 [Escherichia coli O22:H8]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT154266 WP_000138932.1 NZ_CP051483:2702277-2702570 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT154266 NZ_CP067426:c3165477-3165414 [Escherichia coli O22:H8]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A641A3V2


Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References