Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 2702277..2702791 | Replicon | chromosome |
Accession | NZ_CP051483 | ||
Organism | Staphylococcus aureus strain NGA66a |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | A0A641A3V2 |
Locus tag | HGO94_RS13365 | Protein ID | WP_000581793.1 |
Coordinates | 2702582..2702791 (+) | Length | 70 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | W8UW13 |
Locus tag | HGO94_RS13360 | Protein ID | WP_000138932.1 |
Coordinates | 2702277..2702570 (+) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HGO94_RS13340 (2697739) | 2697739..2698380 | + | 642 | WP_000483155.1 | thiamine phosphate synthase | - |
HGO94_RS13345 (2698466) | 2698466..2699338 | + | 873 | WP_000725802.1 | membrane protein insertase YidC | - |
HGO94_RS13350 (2699952) | 2699952..2700599 | - | 648 | WP_001187628.1 | HD domain-containing protein | - |
HGO94_RS13355 (2700627) | 2700627..2702111 | - | 1485 | WP_000571549.1 | cardiolipin synthase | - |
HGO94_RS13360 (2702277) | 2702277..2702570 | + | 294 | WP_000138932.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
HGO94_RS13365 (2702582) | 2702582..2702791 | + | 210 | WP_000581793.1 | heavy metal-associated domain-containing protein | Toxin |
HGO94_RS13370 (2702919) | 2702919..2703056 | + | 138 | WP_000828354.1 | Lmo0850 family protein | - |
HGO94_RS13375 (2703319) | 2703319..2704521 | - | 1203 | WP_001109939.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
HGO94_RS13380 (2704839) | 2704839..2705909 | + | 1071 | WP_000159627.1 | D-alanine--D-alanine ligase | - |
HGO94_RS13385 (2705924) | 2705924..2707282 | + | 1359 | WP_054193129.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7809.75 Da Isoelectric Point: 4.1008
>T154266 WP_000581793.1 NZ_CP051483:2702582-2702791 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI
Download Length: 210 bp
>T154266 NZ_CP067426:3165527-3165634 [Escherichia coli O22:H8]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11197.82 Da Isoelectric Point: 6.2243
>AT154266 WP_000138932.1 NZ_CP051483:2702277-2702570 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
Download Length: 294 bp
>AT154266 NZ_CP067426:c3165477-3165414 [Escherichia coli O22:H8]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A641A3V2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | W8UW13 |