Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1225884..1226361 | Replicon | chromosome |
| Accession | NZ_CP051483 | ||
| Organism | Staphylococcus aureus strain NGA66a | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | HGO94_RS06230 | Protein ID | WP_000052076.1 |
| Coordinates | 1226173..1226361 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | HGO94_RS06225 | Protein ID | WP_001059690.1 |
| Coordinates | 1225884..1226144 (+) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HGO94_RS06190 (1221279) | 1221279..1221995 | - | 717 | WP_000150012.1 | type I 3-dehydroquinate dehydratase | - |
| HGO94_RS06195 (1222143) | 1222143..1222565 | + | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| HGO94_RS06200 (1222964) | 1222964..1223458 | + | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| HGO94_RS06205 (1223613) | 1223613..1224230 | + | 618 | WP_054193003.1 | LysE/ArgO family amino acid transporter | - |
| HGO94_RS06210 (1224303) | 1224303..1224884 | - | 582 | WP_001140696.1 | histidine phosphatase family protein | - |
| HGO94_RS06215 (1225108) | 1225108..1225344 | + | 237 | WP_000368687.1 | hypothetical protein | - |
| HGO94_RS06220 (1225341) | 1225341..1225544 | - | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| HGO94_RS06225 (1225884) | 1225884..1226144 | + | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| HGO94_RS06230 (1226173) | 1226173..1226361 | + | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| HGO94_RS06235 (1226549) | 1226549..1227118 | + | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| HGO94_RS06240 (1227206) | 1227206..1227490 | + | 285 | WP_001004401.1 | hypothetical protein | - |
| HGO94_RS06245 (1227552) | 1227552..1227770 | + | 219 | WP_000005886.1 | hypothetical protein | - |
| HGO94_RS06250 (1228266) | 1228266..1228466 | - | 201 | WP_001059082.1 | cold-shock protein | - |
| HGO94_RS06255 (1228823) | 1228823..1229509 | - | 687 | WP_001793574.1 | thermonuclease family protein | - |
| HGO94_RS06260 (1229850) | 1229850..1230371 | - | 522 | WP_000824464.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | selq / selk / vWbp / clfA | 1201182..1239427 | 38245 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T154257 WP_000052076.1 NZ_CP051483:1226173-1226361 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T154257 NZ_CP067426:961856-962230 [Escherichia coli O22:H8]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGATTCTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAATTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCTGGAGGCGAAATGA
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCATCATCTGGCAGATTCTGCTCAC
CCGACTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAATTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATCCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCTGGAGGCGAAATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT154257 WP_001059690.1 NZ_CP051483:1225884-1226144 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT154257 NZ_CP067426:961398-961766 [Escherichia coli O22:H8]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GTCCTGTTTCGGCGCCCGTCTGGTGCAGGTGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGTTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GTCCTGTTTCGGCGCCCGTCTGGTGCAGGTGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGTTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACCCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |