154254

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tsbAT/-
Location 120041..120817 Replicon chromosome
Accession NZ_CP051483
Organism Staphylococcus aureus strain NGA66a

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag HGO94_RS00780 Protein ID WP_000031108.1
Coordinates 120665..120817 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag HGO94_RS00775 Protein ID WP_001251224.1
Coordinates 120041..120640 (+) Length 200 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HGO94_RS00755 (115957) 115957..117414 + 1458 WP_054192983.1 ABC transporter permease subunit -
HGO94_RS00760 (117407) 117407..118129 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
HGO94_RS00765 (118280) 118280..119407 + 1128 WP_000379987.1 tRNA epoxyqueuosine(34) reductase QueG -
HGO94_RS00770 (119412) 119412..119882 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
HGO94_RS00775 (120041) 120041..120640 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
HGO94_RS00780 (120665) 120665..120817 + 153 WP_000031108.1 SAS053 family protein Toxin
HGO94_RS00785 (121423) 121423..121818 + 396 WP_000901023.1 hypothetical protein -
HGO94_RS00790 (122014) 122014..123399 + 1386 WP_000116229.1 class II fumarate hydratase -
HGO94_RS00795 (123860) 123860..124681 - 822 WP_249741400.1 RluA family pseudouridine synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(124-196)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T154254 WP_000031108.1 NZ_CP051483:120665-120817 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T154254 NZ_CP067426:387257-387532 [Escherichia coli O22:H8]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATAGTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGCAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT154254 WP_001251224.1 NZ_CP051483:120041-120640 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT154254 NZ_CP067426:387529-387888 [Escherichia coli O22:H8]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB X5E2E6


Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References